About: Effect of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation

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About: Effect of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In the present study, we investigated impact of silymarin, its constituents and a series of their synthetic derivatives on ER- and AhR-mediated activities. Silymarin elicited partial ER activation, with silybin B being probably responsible for a majority of the weak ER-mediated activity of silymarin, while the synthetic silybin derivatives, potentially useful as chemoprotective agents, did not modulate the ER-mediated activity, with exception of 23-O-pivaloylsilybin. In conclusion, our data suggest that estrogenicity of some silymarin constituents, and biological activities of their purified or synthesized diastereomers, should be taken in account as their potential side effect when considered as chemopreventive compounds. In the present study, we investigated impact of silymarin, its constituents and a series of their synthetic derivatives on ER- and AhR-mediated activities. Silymarin elicited partial ER activation, with silybin B being probably responsible for a majority of the weak ER-mediated activity of silymarin, while the synthetic silybin derivatives, potentially useful as chemoprotective agents, did not modulate the ER-mediated activity, with exception of 23-O-pivaloylsilybin. In conclusion, our data suggest that estrogenicity of some silymarin constituents, and biological activities of their purified or synthesized diastereomers, should be taken in account as their potential side effect when considered as chemopreventive compounds. (en)
Title	Effect of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation Effect of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation (en)
skos:prefLabel	Effect of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation Effect of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation (en)
skos:notation	RIV/68081707:_____/05:00022152!RIV11-GA0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA303/02/1097), Z(AV0Z50040507), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vondráček, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	519434
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/05:00022152
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	estrogenicity; dioxin-like activity; silybin derivatives (en)
http://linked.open.../riv/klicoveSlovo	estrogenicity silybin derivatives dioxin-like activity
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[7C03676B3A12]
http://linked.open...i/riv/nazevZdroje	Toxicology
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Synthesis and Biological Characterization of New Compounds Derived from Silibinin for Potential Use as Chemoprotectants in Dermatology
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	215
http://linked.open...iv/tvurceVysledku	Gažák, Radek Křen, Vladimír Machala, M. Vondráček, Jan Sedmera, Petr Šimánek, V. Plíšková, M. Walterová, D. Psotová, J.
http://linked.open...ain/vavai/riv/wos	000233125300007
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Microorganisms in Research and Biotechnology
issn	0300-483X
number of pages	10 (xsd:int)

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