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| rdf:type
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| Description
| - We have compared colorectal carcinoma tissues with parallel samples of epithelial tissue and identified, by means of Human 1.7K cDNA microarrays, a set of genes with significantly altered expression in 12 patients. We used a combination of several approaches of microarray data analysis to be sure that the results were reliable. Although we have found differences between the results obtained by various image analysis software packages and using different statistical tools, we have identified the group of 22 genes with significantly altered expression in colorectal carcinoma tissue as compared with epithelial tissue using all evaluation approaches. Hierarchical clustering showed the possibility of dividing the patients into two groups according to the presence of metastases in regional lymph nodes. We have proposed 6 genes as potential markers for the detection of the presence of regional metastases in patients.
- We have compared colorectal carcinoma tissues with parallel samples of epithelial tissue and identified, by means of Human 1.7K cDNA microarrays, a set of genes with significantly altered expression in 12 patients. We used a combination of several approaches of microarray data analysis to be sure that the results were reliable. Although we have found differences between the results obtained by various image analysis software packages and using different statistical tools, we have identified the group of 22 genes with significantly altered expression in colorectal carcinoma tissue as compared with epithelial tissue using all evaluation approaches. Hierarchical clustering showed the possibility of dividing the patients into two groups according to the presence of metastases in regional lymph nodes. We have proposed 6 genes as potential markers for the detection of the presence of regional metastases in patients. (en)
- Tato práce je zaměřená na porovnání genové exprese kolorektálního karcinomu a zdravé epiteliální tkáně tlustého střeva pomocí Human 1.7K cDNA mikročipů a identifikace genů se změněnou expresí v nádorové tkáni. Tato studie byla provedena na 12 pacientech s nádorem tlustého střeva. Pro zajištění důvěryhodnosti dat byla analýza cDNA microarray provedena kombinací několika programů pro analýzu obrazu a statistických metod. Výsledkem této analýzy byla identifikace 22 genů se změněnou expresí v nádorové tkáni oproti zdravému epitelu. Pomocí hierarchického klastrování byla provedena klasifikace pacientů s kolorektálním karcinomem podle výskytu metastáz v lymfatických uzlinách a bylo detekováno 6 genů, které by mohly sloužit jako potenciální metastatické markery. (cs)
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| Title
| - Gene expression in colorectal carcinoma determined by cDNA microarrays using a combination of several evaluation approaches
- Analýza genové exprese kolorektálního karcinomu detekované cDNA mikročipy pomocí kombinace různých vyhodnocovacích přístupů (cs)
- Gene expression in colorectal carcinoma determined by cDNA microarrays using a combination of several evaluation approaches (en)
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| skos:prefLabel
| - Gene expression in colorectal carcinoma determined by cDNA microarrays using a combination of several evaluation approaches
- Analýza genové exprese kolorektálního karcinomu detekované cDNA mikročipy pomocí kombinace různých vyhodnocovacích přístupů (cs)
- Gene expression in colorectal carcinoma determined by cDNA microarrays using a combination of several evaluation approaches (en)
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| skos:notation
| - RIV/68081707:_____/04:00108488!RIV/2005/AV0/A17005/N
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA202/02/0804), P(GA202/04/0907), P(IAA5004306), P(KSK5052113), P(ME 565), P(NC6987), Z(AV0Z5004920), Z(MSM 143300002)
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/04:00108488
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - gene expression; colorectal carcinoma; cDNA microarrays (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...v/mistoKonaniAkce
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - Biophysics of the Genome: Proceedings of the Workshop Held at Brno
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Jarošová, M.
- Kozubek, Stanislav
- Žaloudík, J.
- Pavlík, T.
- Kozubek, M.
- Svoboda, Z.
- Jansová, E.
- Koutná, I.
- Krontorád, P.
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| http://linked.open...vavai/riv/typAkce
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| http://linked.open.../riv/zahajeniAkce
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| http://linked.open...n/vavai/riv/zamer
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| number of pages
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| http://purl.org/ne...btex#hasPublisher
| - Masarykova univerzita v Brně
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| https://schema.org/isbn
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