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| rdf:type
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| Description
| - The 3´-azido-3´-deoxythymidine (AZT, Zidovudine) is an antiproliferative and virostatic drug widely used in human immunodeficiency virus type 1 (HIV-1) infection treatment. With respect to side effects of high doses and a short half-life of AZT, a fast and simple detection method for this agent could be helpful. The aim of our study was to determine AZT levels in natural samples (urine, serum, whole blood, and cell cultures, such as the HaCaT line of keratinocytes) without their mineralization and/or purification, by means of electrochemical methods using hanging mercury drop electrode (HMDE). On this electrode, AZT undergoes irreversible reduction at the peak potential near E-p - 1.1 V (vs. Ag/AgCl/3 M KCl). Reduction AZT signals were measured by cyclic voltammetry (CV), differential pulse voltammetry (DPV), square-wave voltammetry (SWV), and constant current chronopotentiometric stripping analysis (CPSA).
- The 3´-azido-3´-deoxythymidine (AZT, Zidovudine) is an antiproliferative and virostatic drug widely used in human immunodeficiency virus type 1 (HIV-1) infection treatment. With respect to side effects of high doses and a short half-life of AZT, a fast and simple detection method for this agent could be helpful. The aim of our study was to determine AZT levels in natural samples (urine, serum, whole blood, and cell cultures, such as the HaCaT line of keratinocytes) without their mineralization and/or purification, by means of electrochemical methods using hanging mercury drop electrode (HMDE). On this electrode, AZT undergoes irreversible reduction at the peak potential near E-p - 1.1 V (vs. Ag/AgCl/3 M KCl). Reduction AZT signals were measured by cyclic voltammetry (CV), differential pulse voltammetry (DPV), square-wave voltammetry (SWV), and constant current chronopotentiometric stripping analysis (CPSA). (en)
- 3´-azido-3´-deoxythymidin (AZT, Zidovudine) je antiproliferativní a virostatické léčivo, široce používané v léčbě lidské imunodeficience typu 1 (HIV-1). S ohledem na vedlejší účinky vysokých dávek a krátkého poločasu rozkladu AZT je žádoucí mít k disposici rychlou a jednoduchou metodu detekce tohoto agens. Cílem naší studie bylo stanovit hladiny AZT v přirozených vzorcích (v moči, v séru, v celé krvi a v buněčných kulturách, jako HaCaT linii keratinocytů) bez jejich mineralizace a/nebo purifikace, pomocí elektrochemických metod s použitím visící rtuťové kapky (HMDE). Na této elektrodě AZT poskytuje irreversibilní redukční pík blízko potenciálu E-p -1.1 V (vs. Ag/AgCl/3M KCl). Redukční signály AZT byly měřeny cyklickou voltametrií, diferenční pulsní voltametrií, sqare-wave voltametrií a chronopotenciometrickou stripovací analýzou při konstantním proudu (CPSA). (cs)
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| Title
| - Determination of azidothymidine - an antiproliferative and virostatic drug by square-wave voltammetry
- Stanovení azidothymidinu – antiproliferativního a virostatického léčiva pomocí sqare wave voltametrie (cs)
- Determination of azidothymidine - an antiproliferative and virostatic drug by square-wave voltammetry (en)
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| skos:prefLabel
| - Determination of azidothymidine - an antiproliferative and virostatic drug by square-wave voltammetry
- Stanovení azidothymidinu – antiproliferativního a virostatického léčiva pomocí sqare wave voltametrie (cs)
- Determination of azidothymidine - an antiproliferative and virostatic drug by square-wave voltammetry (en)
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| skos:notation
| - RIV/68081707:_____/04:00104697!RIV/2005/AV0/A17005/N
|
| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA203/02/0422), P(IAA1163201), P(IBS5004009), Z(AV0Z5004920)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/04:00104697
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - azidothymidine (AZT); square-wave voltammetry; hanging mercury drop electrode (HMDE) (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Andrysík, Zdeněk
- Kizek, René
- Vacek, Jan
- Trnková, L.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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