| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Cílem studie bylo zkoumat účinky stabilních agonistů adenosinových receptorů ma krvetvorbu v kostní dřeni při využití modelu myelosuprese vyvolané 5-fluorouracilem (5-FU), látkou specificky cytotoxickou pro buňky v cyklu. Byly vyhodnocovány efekty nespecifického agonisty NECA, aktivujícího všechny známé adenosinové receptory (A(1), A(2A), A(2)B, A(3)) a agonistů specifických pro A(1) (CPA), A(2A) (CGS 21680) a A(3) (IB-MECA) receptory. Experimenty byly provedeny na B10CBAF1 myších za in vivo podmínek. Agonisté adenosinových receptorů byli podáváni v podobě jedné injekce před aplikací 5-FU a účinky byly sledovány 4 dny později. Počty jaderných buněk kostní dřeně femuru a krvetvorné progenitorové buňky (GM-CFC a BFU-E) byly použity jako ukazatele účinnosti terapie. (cs)
- The aim of the study was to investigate the effects of stable adenosine receptor agonists on bone marrow hematopoiesis by utilizing the model of hematopoietic damage induced by 5-fluorouracil (5-FU), a cycle-specific cytotoxic agent. Effects of a non-selective agonist NECA activating all the known adenosine receptors (A(1), A(2A), A(2B), A(3)) and of the selective agonists for A(1) (CPA), A(2A) (CGS 21680), and A(3) (IB-MECA) adenosine receptors were investigated. Experiments were performed with B10CBAF1 mice under in vivo conditions. Adenosine receptor agonists were given in single injections before 5-FU administration and the effects were determined 4 days later. The numbers of femoral marrow nucleated cells and hematopoietic progenitor cells (CFC-GM and BFU-E) were taken as indices of the effects.
- The aim of the study was to investigate the effects of stable adenosine receptor agonists on bone marrow hematopoiesis by utilizing the model of hematopoietic damage induced by 5-fluorouracil (5-FU), a cycle-specific cytotoxic agent. Effects of a non-selective agonist NECA activating all the known adenosine receptors (A(1), A(2A), A(2B), A(3)) and of the selective agonists for A(1) (CPA), A(2A) (CGS 21680), and A(3) (IB-MECA) adenosine receptors were investigated. Experiments were performed with B10CBAF1 mice under in vivo conditions. Adenosine receptor agonists were given in single injections before 5-FU administration and the effects were determined 4 days later. The numbers of femoral marrow nucleated cells and hematopoietic progenitor cells (CFC-GM and BFU-E) were taken as indices of the effects. (en)
|
| Title
| - Effects of stable adenosine receptor agonists on bone marrow haematopoietic cells as inferred from the cytotoxic action of 5-fluorouracil
- Effects of stable adenosine receptor agonists on bone marrow haematopoietic cells as inferred from the cytotoxic action of 5-fluorouracil (en)
- Účinky stabilních agonistů adenosinových receptorů na krvetvorné buňky kostní dřeně poškozené cytotoxickým působením 5-fluorouracilu (cs)
|
| skos:prefLabel
| - Effects of stable adenosine receptor agonists on bone marrow haematopoietic cells as inferred from the cytotoxic action of 5-fluorouracil
- Effects of stable adenosine receptor agonists on bone marrow haematopoietic cells as inferred from the cytotoxic action of 5-fluorouracil (en)
- Účinky stabilních agonistů adenosinových receptorů na krvetvorné buňky kostní dřeně poškozené cytotoxickým působením 5-fluorouracilu (cs)
|
| skos:notation
| - RIV/68081707:_____/04:00104659!RIV/2005/AV0/A17005/N
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA305/02/0423), P(IBS5004009), P(KSK5011112), Z(AV0Z5004920)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/04:00104659
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - adenosine receptor agonists; hematopoiesis; 5-fluorouracil (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Hofer, Michal
- Pospíšil, Milan
- Vacek, Antonín
- Znojil, V.
- Pipalová, I.
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)