| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Ačkoliv je řada polycyklických aromatických uhlovodíků (PAHs) považována za silné mutageny a karcinogeny, o jejich roli v nádorové promoci je známo relativně málo. Bylo prokázáno, že 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) může indukovat uvolnění krysích jaterních oválných epiteliálních buněk z kontaktní inhibice mechanismem pravděpodobně zahrnujícím aktivaci receptoru pro aromatické uhlovodíky (AhR). Řada PAHs jsou ligandy AhR, a také je známo, že působí jako přechodné induktory aktivity zprostředkované AhR. V této práci byly zkoumány efekty 19 vybraných PAHs na proliferaci konfluentní populace krysích jaterních epiteliálních buněk WB-F344. Výsledky této studie napovídají, že uvolnění z kontaktní inhibice může být součástí účinků PAHs aktivujících AhR, což vede k nádorové promoci; nicméně s tímto procesem by mohly také interferovat genotoxické účinky některých PAHs spojené s aktivací p53. (cs)
- Although many polycyclic aromatic hydrocarbons (PAHs) are recognized as potent mutagens and carcinogens, relatively little is known about their role in the tumor promotion. It is known that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can induce release of rat hepatic oval epithelial cells from contact inhibition by a mechanism possibly involving the aryl hydrocarbon receptor (AhR) activation. Many PAHs are AhR ligands and are known to act as transient inducers of AhR-mediated activity. In this study, effects of 19 selected PAHs on proliferation of confluent rat liver epithelial WB-F344 cells were investigated. The results of the present study seem to suggest that a release from contact inhibition could be a part of tumor promoting effects of AhR-activating PAHs; however, the genotoxic effects of some PAHs associated with p53 activation might interfere with this process.
- Although many polycyclic aromatic hydrocarbons (PAHs) are recognized as potent mutagens and carcinogens, relatively little is known about their role in the tumor promotion. It is known that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can induce release of rat hepatic oval epithelial cells from contact inhibition by a mechanism possibly involving the aryl hydrocarbon receptor (AhR) activation. Many PAHs are AhR ligands and are known to act as transient inducers of AhR-mediated activity. In this study, effects of 19 selected PAHs on proliferation of confluent rat liver epithelial WB-F344 cells were investigated. The results of the present study seem to suggest that a release from contact inhibition could be a part of tumor promoting effects of AhR-activating PAHs; however, the genotoxic effects of some PAHs associated with p53 activation might interfere with this process. (en)
|
| Title
| - Polycyclic aromatic hydrocarbons modulate cell proliferation in rat hepatic epithelial stem-like WB-F344 cells
- Polycyklické aromatické uhlovodíky modulují proliferaci krysích jaterních epiteliálních „kmenových“ buněk WB-F344 (cs)
- Polycyclic aromatic hydrocarbons modulate cell proliferation in rat hepatic epithelial stem-like WB-F344 cells (en)
|
| skos:prefLabel
| - Polycyclic aromatic hydrocarbons modulate cell proliferation in rat hepatic epithelial stem-like WB-F344 cells
- Polycyklické aromatické uhlovodíky modulují proliferaci krysích jaterních epiteliálních „kmenových“ buněk WB-F344 (cs)
- Polycyclic aromatic hydrocarbons modulate cell proliferation in rat hepatic epithelial stem-like WB-F344 cells (en)
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| skos:notation
| - RIV/68081707:_____/04:00104653!RIV/2005/AV0/A17005/N
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA525/03/1527), P(GP525/01/D076), Z(AV0Z5004920)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/04:00104653
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - polycyclic aromatic hydrocarbons; contact inhibition; rat liver epithelial cells (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Toxicology and Applied Pharmacology
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Kozubík, Alois
- Machala, M.
- Vondráček, Jan
- Vojtěšek, B.
- Šindlerová, Lenka
- Chramostová, Kateřina
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
| |
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