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| rdf:type
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| Description
| - Identifikace mechanismů modulace apoptózy indukované pomocí TRAIL (TNF-related apoptosis-inducing ligand) je důležitá pro jeho potenciální využití v protinádorové terapii. Etanol může indukovat buněčnou smrt jak in vitro, tak in vivo pomocí různých signálních drah. Jeho účinek v kombinaci s ligandy smrti je neznámý. Studovali jsme, zda etanol ovlivňuje účinek TRAILu na nádorové buňky tlustého střeva. Po společném působení TRAILu a etanolu jsme prokázali posílení aktivace kaspázy-8, -9, -3, štěpení pro-apoptotického proteinu Bid, snížení mitochondriálního membránového potenciálu, kompletní štěpení poly(ADP)ribosyl polymerázy a vymizení anti-apoptotického proteinu Mcl-1. Etanol zvyšuje citlivost střevních nádorových buněk k apoptóze indukované TRAILem. (cs)
- Identification of mechanisms of modulation of the TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis is important for its potential use in anticancer therapy. Ethanol can induce cell death in vitro and in vivo by different signalling pathways. Its effect in combination with death ligands is unknown. We investigated how ethanol modulates the effects of TRAIL in colon cancer cells. After combined TRAIL and ethanol treatment, a potentiation of caspase-8, -9, -3 activation, a proapoptotic Bid protein cleavage, a decrease of mitochondrial membrane potential, a complete poly(ADP)ribose polymerase cleavage, and disappearance of antiapoptotic Mcl-1 protein were demonstrated. Ethanol acts as a potent agent sensitizing colon cancer cells to TRAIL-induced apoptosis.
- Identification of mechanisms of modulation of the TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis is important for its potential use in anticancer therapy. Ethanol can induce cell death in vitro and in vivo by different signalling pathways. Its effect in combination with death ligands is unknown. We investigated how ethanol modulates the effects of TRAIL in colon cancer cells. After combined TRAIL and ethanol treatment, a potentiation of caspase-8, -9, -3 activation, a proapoptotic Bid protein cleavage, a decrease of mitochondrial membrane potential, a complete poly(ADP)ribose polymerase cleavage, and disappearance of antiapoptotic Mcl-1 protein were demonstrated. Ethanol acts as a potent agent sensitizing colon cancer cells to TRAIL-induced apoptosis. (en)
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| Title
| - Ethanol acts as a potent agent sensitizing colon cancer cells to the TRAIL-induced apoptosis
- Etanol zvyšuje citlivost nádorových buněk tlustého střeva k apoptóze indukované TRAILem (cs)
- Ethanol acts as a potent agent sensitizing colon cancer cells to the TRAIL-induced apoptosis (en)
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| skos:prefLabel
| - Ethanol acts as a potent agent sensitizing colon cancer cells to the TRAIL-induced apoptosis
- Etanol zvyšuje citlivost nádorových buněk tlustého střeva k apoptóze indukované TRAILem (cs)
- Ethanol acts as a potent agent sensitizing colon cancer cells to the TRAIL-induced apoptosis (en)
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| skos:notation
| - RIV/68081707:_____/04:00104650!RIV/2005/AV0/A17005/N
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA524/04/0895), P(IBS5004009), P(KSK5011112), Z(AV0Z5004920)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/04:00104650
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - TNF-related apoptosis-inducing ligand; ethanol; apoptosis (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Anděra, Ladislav
- Hofmanová, Jiřina
- Kozubík, Alois
- Souček, Karel
- Vaculová, Alena
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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