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Description
| - Interleukin-3 (IL-3) stimulated human leukemic K 562 cells were used as a model system in which nuclear organization and expression of the beta-like globin gene cluster was investigated. Conserved nuclear location of beta-like globin gene clusters was found in both control and IL-3 treated cells, which indicates that changes in cluster gene expression are associated with a stable nuclear topography. The studied type of cell differentiation was characterized by relocation of chromosome 11 and its centromeric regions closer to the nuclear periphery, which seems to be a general feature of many pathways of cellular maturation.
- Interleukin-3 (IL-3) stimulated human leukemic K 562 cells were used as a model system in which nuclear organization and expression of the beta-like globin gene cluster was investigated. Conserved nuclear location of beta-like globin gene clusters was found in both control and IL-3 treated cells, which indicates that changes in cluster gene expression are associated with a stable nuclear topography. The studied type of cell differentiation was characterized by relocation of chromosome 11 and its centromeric regions closer to the nuclear periphery, which seems to be a general feature of many pathways of cellular maturation. (en)
- Lidské leukemické buňky K 562 stimulované interleukinem-3 (IL-3) byly použity jako modelový systém pro studium jaderného uspořádání a exprese beta-like globinového klastru genů. Konzervované umístění beta-like globinového klastru genů v jádře bylo pozorováno u kontrolních i IL-3 stimulovaných buněk, což naznačuje, že změny v expresi genového klastru jsou spojeny se stabilní jadernou topografií. Studovaný typ buněčné diferenciace byl charakterizován přemístěním chromozomu 11 a jeho centromerických oblastí blíže k jaderné periferii, což je zřejmě hlavní vlastnost mnoha cest buněčného dozrávání. (cs)
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Title
| - Nuclear topography of beta-like globin gene cluster in IL-3-stimulated human leukemic K-562 cells
- Jaderná topografie beta-like globinového klastru genů u lidských leukemických buněk stimulovaných IL-3 (cs)
- Nuclear topography of beta-like globin gene cluster in IL-3-stimulated human leukemic K-562 cells (en)
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skos:prefLabel
| - Nuclear topography of beta-like globin gene cluster in IL-3-stimulated human leukemic K-562 cells
- Jaderná topografie beta-like globinového klastru genů u lidských leukemických buněk stimulovaných IL-3 (cs)
- Nuclear topography of beta-like globin gene cluster in IL-3-stimulated human leukemic K-562 cells (en)
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skos:notation
| - RIV/68081707:_____/04:00104634!RIV/2005/AV0/A17005/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA202/04/0907), P(GA301/01/0186), P(IAA5004306), P(KSK5052113), P(ME 565), Z(AV0Z5004920)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/04:00104634
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - beta-like globin gene cluster; K-562 cells; nuclear topography (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Blood Cells, Molecules, and Diseases
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Bártová, Eva
- Kozubek, Stanislav
- Galiová, Gabriela
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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