About: Trichostatin a suppresses transformation by the v-myb oncogene in BM2 cells.

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About: Trichostatin a suppresses transformation by the v-myb oncogene in BM2 cells. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	BM2 cells are chicken monoblasts transformed by the v-myb oncogene of avian myeloblastosis virus. The constitutively high v-myb expression interferes with the terminal differentiation of BM2 cells, but these cells can be induced to differentiate into macrophage-like cells by phorbol esters. Histone acetylation plays an important role in regulation of transcription and is particularly relevant to the regulation and pathology of hematopoiesis. In the present study, we examined the contribution of elevated histone acetylation to the differentiation of BM2 cells. Inhibition of the activity of endogenous histone deacetylases by trichostatin A (TSA) resulted in histone hyperacetylation causing cell cycle arrest and differentiation of BM2 cells into macrophage polykaryons. TSA did not affect the level of v-Myb protein in BM2 cells, but it downregulated its transcription activation capability. BM2 cells are chicken monoblasts transformed by the v-myb oncogene of avian myeloblastosis virus. The constitutively high v-myb expression interferes with the terminal differentiation of BM2 cells, but these cells can be induced to differentiate into macrophage-like cells by phorbol esters. Histone acetylation plays an important role in regulation of transcription and is particularly relevant to the regulation and pathology of hematopoiesis. In the present study, we examined the contribution of elevated histone acetylation to the differentiation of BM2 cells. Inhibition of the activity of endogenous histone deacetylases by trichostatin A (TSA) resulted in histone hyperacetylation causing cell cycle arrest and differentiation of BM2 cells into macrophage polykaryons. TSA did not affect the level of v-Myb protein in BM2 cells, but it downregulated its transcription activation capability. (en)
Title	Trichostatin a suppresses transformation by the v-myb oncogene in BM2 cells. Trichostatin a suppresses transformation by the v-myb oncogene in BM2 cells. (en)
skos:prefLabel	Trichostatin a suppresses transformation by the v-myb oncogene in BM2 cells. Trichostatin a suppresses transformation by the v-myb oncogene in BM2 cells. (en)
skos:notation	RIV/68081707:_____/03:17033127!RIV/2004/AV0/A17004/N
http://linked.open.../vavai/riv/strany	225;235
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/03/1055), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Souček, Karel Kubala, Lukáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	631573
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/03:17033127
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	v-myb; trichostatin A; differentation (en)
http://linked.open.../riv/klicoveSlovo	trichostatin A differentation v-myb
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[21FC0490BF84]
http://linked.open...i/riv/nazevZdroje	Journal of Hematotherapy and Stem Cell Research
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of molecular mechanisms causing v-Myb suppression using proteomics-based approach
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Kubala, Lukáš Souček, Karel Šmarda, J. Nemajerová, A. Jurdic, P. Šmardová, J.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	1525-8165
number of pages	11 (xsd:int)

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