About: Effects of adenosine on the growth of murine G:5:113 fibrosarcoma cells in vitro.

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About: Effects of adenosine on the growth of murine G:5:113 fibrosarcoma cells in vitro. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	It has been observed that adenosine suppresses the growth of G:5:113 murine fibrosarcoma cells in vitro with EC50 of 178 mM. Changes in the cell cycle including decreased percentage of cells in S-phase, increased portion of cells in G(0)/G(1)-phase, as well as prolonged generation time were found to be responsible for the growth suppression. Dipyridamole, a drug inhibiting the cellular uptake of adenosine, enhanced the growth suppression induced with adenosine in concentrations of 100 and 200 muM. It follows from these results that the action of adenosine on the G:5:113 cells is extracellular, mediated by adenosine receptors. Elevation of extracellular adenosine might serve potentially as an anticancer therapeutic agent. It has been observed that adenosine suppresses the growth of G:5:113 murine fibrosarcoma cells in vitro with EC50 of 178 mM. Changes in the cell cycle including decreased percentage of cells in S-phase, increased portion of cells in G(0)/G(1)-phase, as well as prolonged generation time were found to be responsible for the growth suppression. Dipyridamole, a drug inhibiting the cellular uptake of adenosine, enhanced the growth suppression induced with adenosine in concentrations of 100 and 200 muM. It follows from these results that the action of adenosine on the G:5:113 cells is extracellular, mediated by adenosine receptors. Elevation of extracellular adenosine might serve potentially as an anticancer therapeutic agent. (en)
Title	Effects of adenosine on the growth of murine G:5:113 fibrosarcoma cells in vitro. Effects of adenosine on the growth of murine G:5:113 fibrosarcoma cells in vitro. (en)
skos:prefLabel	Effects of adenosine on the growth of murine G:5:113 fibrosarcoma cells in vitro. Effects of adenosine on the growth of murine G:5:113 fibrosarcoma cells in vitro. (en)
skos:notation	RIV/68081707:_____/03:17033076!RIV/2004/AV0/A17004/N
http://linked.open.../vavai/riv/strany	207;210
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/02/0423), P(IBS5004009), P(KSK5011112), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Chramostová, Kateřina Hoferová, Zuzana Pospíšil, Milan Hofer, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	605273
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/03:17033076
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	G:5:113 fibrosarcoma cell line; cell growth; adenosine (en)
http://linked.open.../riv/klicoveSlovo	cell growth G:5:113 fibrosarcoma cell line adenosine
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[7605772385D3]
http://linked.open...i/riv/nazevZdroje	Folia Biologica
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	The effect of adenosine analogs on hematopoiesis Molecular and cellular mechanisms of important diseases Untraditional therapeutic approaches in oncology
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	49
http://linked.open...iv/tvurceVysledku	Hofer, Michal Hoferová, Zuzana Pospíšil, Milan Znojil, V. Minksová, Kateřina
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0015-5500
number of pages	4 (xsd:int)

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