About: Recognition of DNA interstrand cross-link of antitumor cisplatin by HMGB1 protein.

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About: Recognition of DNA interstrand cross-link of antitumor cisplatin by HMGB1 protein. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Short DNA duplexes containing a single interstrand cross-link of cisplatin were probed for recognition by the rat chromosomal protein HMGB1 and its domains A and B. It has been found that the full-length HMGB1 protein and its domain B to which the lysine-rich region (seven amino acid residues) of the A/B linker is attached at the N-terminus (the domain HMGB1b7) specifically recognize DNA interstrand cross-linked by cisplatin. In contrast, no recognition of the interstrand cross-link by the domain B lacking this region or by the domain A with or without this lysine-rich region attached to its C-terminus is noticed. A structural model for the complex formed between the interstrand cross-linked DNA and the domain HMGB1b7 was constructed and refined. The model structure is consistent with the hypothesis that the enhancement of binding affinity afforded by the basic lysine-rich A/B linker is a consequence of its tight binding to the sugar-phosphate backbone of both DNA strands. Short DNA duplexes containing a single interstrand cross-link of cisplatin were probed for recognition by the rat chromosomal protein HMGB1 and its domains A and B. It has been found that the full-length HMGB1 protein and its domain B to which the lysine-rich region (seven amino acid residues) of the A/B linker is attached at the N-terminus (the domain HMGB1b7) specifically recognize DNA interstrand cross-linked by cisplatin. In contrast, no recognition of the interstrand cross-link by the domain B lacking this region or by the domain A with or without this lysine-rich region attached to its C-terminus is noticed. A structural model for the complex formed between the interstrand cross-linked DNA and the domain HMGB1b7 was constructed and refined. The model structure is consistent with the hypothesis that the enhancement of binding affinity afforded by the basic lysine-rich A/B linker is a consequence of its tight binding to the sugar-phosphate backbone of both DNA strands. (en)
Title	Recognition of DNA interstrand cross-link of antitumor cisplatin by HMGB1 protein. Recognition of DNA interstrand cross-link of antitumor cisplatin by HMGB1 protein. (en)
skos:prefLabel	Recognition of DNA interstrand cross-link of antitumor cisplatin by HMGB1 protein. Recognition of DNA interstrand cross-link of antitumor cisplatin by HMGB1 protein. (en)
skos:notation	RIV/68081707:_____/03:17033075!RIV/2004/AV0/A17004/N
http://linked.open.../vavai/riv/strany	1234;1244
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/01/0418), P(GA305/02/1552), P(IAA5004105), P(NL6058), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Vojtíšková, Marie Štros, Michal Delalande, Olivier
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	624816
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/03:17033075
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	platinum complexes; nucleic-acids; base pairs (en)
http://linked.open.../riv/klicoveSlovo	nucleic-acids platinum complexes base pairs
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B68796320AB1]
http://linked.open...i/riv/nazevZdroje	Biochemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Cellular and molecular pharmakology of platinum and ruthenium anticancer drugs Platinated oligonucleotides for selective modulation of gene expression; relations to antisense strategy and development of new drugs. Understanding of binding of RNA polymerace I transcription factor xUBF to DNA Recognition and repair of DNA damage by antitumor platinum drugs.Relations to the development of new anticancer drugs.
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	42
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Vojtíšková, Marie Štros, Michal Delalande, Olivier Kozelka, J. Elizondo-Riojas, M.-A.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0006-2960
number of pages	11 (xsd:int)

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