About: The risk of chronic myeloid leukemia: Can the dose-response curve be U-shaped?

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About: The risk of chronic myeloid leukemia: Can the dose-response curve be U-shaped? Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Chronic myeloid leukemia (CML) is caused by a BCR-ABL translocation in a primitive hematopoietic stem cell (HSC). There is evidence that the number of HSCs in the body is only loosely regulated, perhaps having a 'dead-band' of physiologically acceptable values. The existence of a dead-band suggests that low levels of HSC killing can be permanent, i.e. that low doses can cause permanent reductions in the total number of CML target cells and thus permanent reductions in the subsequent risk of spontaneous CML. Our preliminary calculations indicate that, due to dead-band HSC control, if HSCs are as low dose hypersensitive to killing as epithelial cells, reductions in spontaneous CML risk could cancel the low dose risks of induced CML, i.e. net lifetime CML risk could have a 'U' shaped low dose response. Chronic myeloid leukemia (CML) is caused by a BCR-ABL translocation in a primitive hematopoietic stem cell (HSC). There is evidence that the number of HSCs in the body is only loosely regulated, perhaps having a 'dead-band' of physiologically acceptable values. The existence of a dead-band suggests that low levels of HSC killing can be permanent, i.e. that low doses can cause permanent reductions in the total number of CML target cells and thus permanent reductions in the subsequent risk of spontaneous CML. Our preliminary calculations indicate that, due to dead-band HSC control, if HSCs are as low dose hypersensitive to killing as epithelial cells, reductions in spontaneous CML risk could cancel the low dose risks of induced CML, i.e. net lifetime CML risk could have a 'U' shaped low dose response. (en)
Title	The risk of chronic myeloid leukemia: Can the dose-response curve be U-shaped? The risk of chronic myeloid leukemia: Can the dose-response curve be U-shaped? (en)
skos:prefLabel	The risk of chronic myeloid leukemia: Can the dose-response curve be U-shaped? The risk of chronic myeloid leukemia: Can the dose-response curve be U-shaped? (en)
skos:notation	RIV/68081707:_____/02:17023174!RIV/2003/GA0/A17003/N
http://linked.open.../vavai/riv/strany	106;109
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA202/01/0197), P(GA301/01/0186), P(IBS5004010), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Kozubek, Stanislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	662429
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/02:17023174
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	radiation risk; chronic myeloid leukemia; chromosome translocation (en)
http://linked.open.../riv/klicoveSlovo	chronic myeloid leukemia radiation risk chromosome translocation
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[979949206AAA]
http://linked.open...i/riv/nazevZdroje	Radiation Research
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Investigation of the local control of gene expression using spectral microscopy and omage analysis techniques Ionising radiation as a tool in the investigations of the cell nuclear structure and in the development of new techniques for ecology and medicine Development of new diagnostic techniques for oncology
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	157
http://linked.open...iv/tvurceVysledku	Kozubek, Stanislav Radivoyevitch, T. Sachs, R. K.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0033-7587
number of pages	4 (xsd:int)

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