Attributes | Values |
---|
rdf:type
| |
Description
| - The effects of several structurally different inhibitors of AA metabolism in the human keratinocyte HaCaT cell line were examined. While eicosatetraynoic acid (ETYA), nordihydroguaiaretic acid (NDGA), esculetin and MK-886 reduced proliferation and induced apoptosis of HaCaT cells, the cyclooxygenase inhibitors indomethacin and piroxicam had no such effects. Esculetin induced redistribution of F-actin accompanied by increased cell adhesion and size. Our findings indicate that, in addition to their ability to inhibit cell proliferation and to induce apoptosis, lipoxygenase inhibitors and/or ETYA may also elicit other important physiological responses in HaCaT keratinocytes.
- The effects of several structurally different inhibitors of AA metabolism in the human keratinocyte HaCaT cell line were examined. While eicosatetraynoic acid (ETYA), nordihydroguaiaretic acid (NDGA), esculetin and MK-886 reduced proliferation and induced apoptosis of HaCaT cells, the cyclooxygenase inhibitors indomethacin and piroxicam had no such effects. Esculetin induced redistribution of F-actin accompanied by increased cell adhesion and size. Our findings indicate that, in addition to their ability to inhibit cell proliferation and to induce apoptosis, lipoxygenase inhibitors and/or ETYA may also elicit other important physiological responses in HaCaT keratinocytes. (en)
|
Title
| - Multiple biological effects of inhibitors of arachidonic acid metabolism on human keratinocytes.
- Multiple biological effects of inhibitors of arachidonic acid metabolism on human keratinocytes. (en)
|
skos:prefLabel
| - Multiple biological effects of inhibitors of arachidonic acid metabolism on human keratinocytes.
- Multiple biological effects of inhibitors of arachidonic acid metabolism on human keratinocytes. (en)
|
skos:notation
| - RIV/68081707:_____/02:17023120!RIV/2003/GA0/A17003/N
|
http://linked.open.../vavai/riv/strany
| |
http://linked.open...avai/riv/aktivita
| |
http://linked.open...avai/riv/aktivity
| - P(GA524/98/0190), P(GA524/99/0694), P(IBS5004009), Z(AV0Z5004920), Z(AV0Z5045916)
|
http://linked.open...iv/cisloPeriodika
| |
http://linked.open...vai/riv/dodaniDat
| |
http://linked.open...aciTvurceVysledku
| |
http://linked.open.../riv/druhVysledku
| |
http://linked.open...iv/duvernostUdaju
| |
http://linked.open...titaPredkladatele
| |
http://linked.open...dnocenehoVysledku
| |
http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/02:17023120
|
http://linked.open...riv/jazykVysledku
| |
http://linked.open.../riv/klicovaSlova
| - lipoxygenase; keratinocytes; cell cycle (en)
|
http://linked.open.../riv/klicoveSlovo
| |
http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
|
http://linked.open...ontrolniKodProRIV
| |
http://linked.open...i/riv/nazevZdroje
| - Archives of Dermatological Research
|
http://linked.open...in/vavai/riv/obor
| |
http://linked.open...ichTvurcuVysledku
| |
http://linked.open...cetTvurcuVysledku
| |
http://linked.open...ocetUcastnikuAkce
| |
http://linked.open...nichUcastnikuAkce
| |
http://linked.open...vavai/riv/projekt
| |
http://linked.open...UplatneniVysledku
| |
http://linked.open...v/svazekPeriodika
| |
http://linked.open...iv/tvurceVysledku
| - Andrysík, Zdeněk
- Hampl, Aleš
- Hofmanová, Jiřina
- Kozubík, Alois
- Pacherník, Jiří
- Souček, Karel
- Kovaříková, Martina
|
http://linked.open...n/vavai/riv/zamer
| |
issn
| |
number of pages
| |