About: Different Recognition of DNA Modified by Antitumor Cisplatin and Its Clinically Ineffective trans Isomer by Tumor Suppressor Protein p53.

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About: Different Recognition of DNA Modified by Antitumor Cisplatin and Its Clinically Ineffective trans Isomer by Tumor Suppressor Protein p53. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	DNA interactions of active wild-type human p53 protein with DNA fragments and oligodeoxyribonucleotide duplexes modified by antitumor cisplatin and its clinically ineffective trans isomer was investigated by using gel-mobility-shift assay. The results support the hypothesis that mechanism of antitumor activity of cisplatin may be also associated with its efficiency to affect binding affinity of platinated DNA to active p53 protein DNA interactions of active wild-type human p53 protein with DNA fragments and oligodeoxyribonucleotide duplexes modified by antitumor cisplatin and its clinically ineffective trans isomer was investigated by using gel-mobility-shift assay. The results support the hypothesis that mechanism of antitumor activity of cisplatin may be also associated with its efficiency to affect binding affinity of platinated DNA to active p53 protein (en)
Title	Different Recognition of DNA Modified by Antitumor Cisplatin and Its Clinically Ineffective trans Isomer by Tumor Suppressor Protein p53. Different Recognition of DNA Modified by Antitumor Cisplatin and Its Clinically Ineffective trans Isomer by Tumor Suppressor Protein p53. (en)
skos:prefLabel	Different Recognition of DNA Modified by Antitumor Cisplatin and Its Clinically Ineffective trans Isomer by Tumor Suppressor Protein p53. Different Recognition of DNA Modified by Antitumor Cisplatin and Its Clinically Ineffective trans Isomer by Tumor Suppressor Protein p53. (en)
skos:notation	RIV/68081707:_____/01:17013022!RIV/2003/AV0/A17003/N
http://linked.open.../vavai/riv/strany	16064;16069
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/00/P094), P(GA305/01/0418), P(GA305/99/0695), P(IAA5004101), P(NL6058), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	19
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	677750
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/01:17013022
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Interstrand cross-links; platinum complexes; supercoiled DNA (en)
http://linked.open.../riv/klicoveSlovo	platinum complexes supercoiled DNA Interstrand cross-links
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3C28F40BB9CC]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	The study of mechanisms regulating the activity of p53 protein and the possibilities of its latent forms activation in cancer cell Cellular and molecular pharmakology of platinum and ruthenium anticancer drugs Affection of DNA conformation by metal-based anticancer drugs. Relations to the development of new cytostatics Structure, recognition and biochemistry of DNA modified by antitumor platinum drugs Recognition and repair of DNA damage by antitumor platinum drugs.Relations to the development of new anticancer drugs.
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	276
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Pospíšilová, Š.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0021-9258
number of pages	6 (xsd:int)

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