About: Challenges of Huntington's disease and quest for therapeutic biomarkers

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Challenges of Huntington's disease and quest for therapeutic biomarkers Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Huntington's disease (HD) is the most common inherited neurodegenerative disorder among polyglutamine (polyQ) diseases caused by cytosine-adenine-guanine repeat expansion in exon 1 of the huntingtin gene whose translation results in polyQ stretch in the N-terminus of the huntingtin protein (HD protein). This mutation significantly affects huntingtin conformation, proteolysis, PTMs, as well as its ability to bind interacting proteins. As a consequence, a variety of cellular mechanisms such as transcription, mitochondrial energy metabolism, axonal transport, neuronal vulnerability to oxidative stress, neurotransmission, and immune response are altered and involved in the pathogenesis of HD. Promising candidate molecular biomarkers of HD have emerged from proteomic studies. Recent analyses focused on HD protein itself, its PTM, and interacting proteins, which are of great importance for disease course. Furthermore, brain, body fluids, and immune system are intensively studied in order to search for additional proteins with a view to their use as a biomarker(s) or set of biomarkers in clinical trials in HD translational research. Huntington's disease (HD) is the most common inherited neurodegenerative disorder among polyglutamine (polyQ) diseases caused by cytosine-adenine-guanine repeat expansion in exon 1 of the huntingtin gene whose translation results in polyQ stretch in the N-terminus of the huntingtin protein (HD protein). This mutation significantly affects huntingtin conformation, proteolysis, PTMs, as well as its ability to bind interacting proteins. As a consequence, a variety of cellular mechanisms such as transcription, mitochondrial energy metabolism, axonal transport, neuronal vulnerability to oxidative stress, neurotransmission, and immune response are altered and involved in the pathogenesis of HD. Promising candidate molecular biomarkers of HD have emerged from proteomic studies. Recent analyses focused on HD protein itself, its PTM, and interacting proteins, which are of great importance for disease course. Furthermore, brain, body fluids, and immune system are intensively studied in order to search for additional proteins with a view to their use as a biomarker(s) or set of biomarkers in clinical trials in HD translational research. (en)
Title	Challenges of Huntington's disease and quest for therapeutic biomarkers Challenges of Huntington's disease and quest for therapeutic biomarkers (en)
skos:prefLabel	Challenges of Huntington's disease and quest for therapeutic biomarkers Challenges of Huntington's disease and quest for therapeutic biomarkers (en)
skos:notation	RIV/67985904:_____/15:00441650!RIV15-TA0-67985904
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED2.1.00/03.0124), P(TA01011466)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Žižková, Martina Valeková, Ivona Kotrčová, Eva Motlík, Jan Kovářová, Hana Jarkovská, Karla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	56
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/15:00441650
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HD biomarkers; Huntington´s disease; Huntingtin neurotoxicity; Huntingtin pathogenesis (en)
http://linked.open.../riv/klicoveSlovo	Huntington´s disease HD biomarkers Huntingtin neurotoxicity Huntingtin pathogenesis
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[6CC34E4B7B90]
http://linked.open...i/riv/nazevZdroje	Proteomics Clinical Applications
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	ExAM Experimental Animal Models Biomedical model of miniature pigs for testing of new medicaments and for new treatments of traumatic spinal cord injury and neurodegenerative diseases
http://linked.open...UplatneniVysledku	2015
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Motlík, Jan Gadher, S. J. Jarkovská, Karla Kovářová, Hana Kotrčová, Eva Valeková, Ivona Žižková, Martina
http://linked.open...ain/vavai/riv/wos	000349436400015
issn	1862-8346
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/prca.201400073

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 77 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software