About: Optimized conditions for mesenchymal stem cells to differentiate into osteoblasts on a collagen/hydroxyapatite matrix

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Pulsed laser deposition was proved as a suitable method for hydroxyapatite (HA) coating of coaxial poly-ε-caprolactone/polyvinylalcohol (PCL/PVA) nanofibers. The fibrous morphology of PCL/PVA nanofibers was preserved, if the nanofiber scaffold was coated with a thin layers of HA (200 nm and 400 nm). Increasing thickness of HA, however, resulted in a gradual loss of fibrous character. In addition, biomechanical properties were improved after HA deposition on PCL/PVA nanofibers as the value of Young's moduli of elasticity significantly increased. Cle arly, thin-layer hydroxyapatite deposition on a nanofiber surface stimulated mesenchymal stem cell viability and their differentiation into osteoblasts. The optimal depth of HA was 800 nm. Pulsed laser deposition was proved as a suitable method for hydroxyapatite (HA) coating of coaxial poly-ε-caprolactone/polyvinylalcohol (PCL/PVA) nanofibers. The fibrous morphology of PCL/PVA nanofibers was preserved, if the nanofiber scaffold was coated with a thin layers of HA (200 nm and 400 nm). Increasing thickness of HA, however, resulted in a gradual loss of fibrous character. In addition, biomechanical properties were improved after HA deposition on PCL/PVA nanofibers as the value of Young's moduli of elasticity significantly increased. Cle arly, thin-layer hydroxyapatite deposition on a nanofiber surface stimulated mesenchymal stem cell viability and their differentiation into osteoblasts. The optimal depth of HA was 800 nm. (en)
Title	Optimized conditions for mesenchymal stem cells to differentiate into osteoblasts on a collagen/hydroxyapatite matrix Optimized conditions for mesenchymal stem cells to differentiate into osteoblasts on a collagen/hydroxyapatite matrix (en)
skos:prefLabel	Optimized conditions for mesenchymal stem cells to differentiate into osteoblasts on a collagen/hydroxyapatite matrix Optimized conditions for mesenchymal stem cells to differentiate into osteoblasts on a collagen/hydroxyapatite matrix (en)
skos:notation	RIV/67985904:_____/11:00368158!RIV12-AV0-67985904
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(1M0510), P(2B06130), P(7E09088), P(GA202/09/1151), P(GAP304/10/1307), P(GP106/09/P226), P(IAA500390702), S, Z(AV0Z50390512), Z(AV0Z50390703), Z(AV0Z50450515), Z(MSM4977751303)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Juhásová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	218785
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/11:00368158
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	collagen/HA scaffold; MSCs; osteoblasts (en)
http://linked.open.../riv/klicoveSlovo	MSCs collagen/HA scaffold osteoblasts
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[73CC85CEC311]
http://linked.open...i/riv/nazevZdroje	Journal of Biomedical Materials Research. Part A
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for cardiovascular research Synthesis of new biomaterials and preparation of stem cell derived cells, and their aplications in for the treatment of diseases affecting human tissues derived from mesoderm: cartilage, bone, ligament and meniscus. Focused tandem shock waves and their potential application in cancer treatment and controlled drug delivery BIOactive highly porous and injectable Scaffolds controlling stem cell recruitment, proliferation and differentiation and enabling angiogenesis for Cardiovascular ENgineered Tissues Smart nanofiber/liposme composite scaffold for bone regeneration Development of software with graphical user interface for evaluation of mechanical measurements performed on soft biological tissues Scaffolds from liposome nanofibers for tissue engineering
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	99A
http://linked.open...iv/tvurceVysledku	Amler, Evžen Jakubová, Radka Kochová, P. Prosecká, Eva Rampichová, Michala Tonar, Z. Tvrdík, D. Juhásová, Jana Jančář, J. Klepáček, J. Melčáková, Š. Nečas, A. Plencner, Martin Vojtová, L.
http://linked.open...ain/vavai/riv/wos	000295142400018
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie New biotechnologies, nanomaterials and stem cells for use in regenerative medicine Genetic, functional and developmental potential of animal cells, tissues and organisms: their use in medicine, ecology and agriculture Predikce poruch heterogenních materiálů, komponent mechanických a biomechanických systémů.
issn	1549-3296
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/jbm.a.33189

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