About: Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition

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About: Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Commensal bacteria have been shown to modulate the host mucosal immune system. Here, we report that oral treatment of BALB/c mice with components from the commensal, Parabacteroides distasonis, significantly reduces the severity of intestinal inflammation in murine models of acute and chronic colitis induced by dextran sulphate sodium (DSS). The membranous fraction of P. distasonis (mPd) prevented DSS-induced increases in several proinflammatory cytokines, increased mPd-specific serum antibodies and stabilized the intestinal microbial ecology Commensal bacteria have been shown to modulate the host mucosal immune system. Here, we report that oral treatment of BALB/c mice with components from the commensal, Parabacteroides distasonis, significantly reduces the severity of intestinal inflammation in murine models of acute and chronic colitis induced by dextran sulphate sodium (DSS). The membranous fraction of P. distasonis (mPd) prevented DSS-induced increases in several proinflammatory cytokines, increased mPd-specific serum antibodies and stabilized the intestinal microbial ecology (en)
Title	Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition (en)
skos:prefLabel	Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition (en)
skos:notation	RIV/67985904:_____/11:00363004!RIV12-AV0-67985904
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500200572), P(GA303/08/0367), P(GA305/08/0535), P(GD310/08/H077), P(IAA5020205), P(KJB500200904), Z(AV0Z50200510), Z(AV0Z50450515)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Mrázek, Jakub Kopečný, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	218826
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/11:00363004
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	animal models; cytokines/interleukins; DSS colitis (en)
http://linked.open.../riv/klicoveSlovo	DSS colitis animal models cytokines/interleukins
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[30641EDBACFE]
http://linked.open...i/riv/nazevZdroje	Clinical and Experimental Immunology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Prophylactic and therapeutic effect of probiotics on experimentally induced intestinal inflammation Analysis of antiinflammatory properties of selected substances of bacterial and plant origin in experimental colitis therapy and prevention Development of new tools for diagnosis and therapy of CrohnŮs disease and ulcerative colitis Inflammatory bowel disease: From immunopathogenetic mechanisms to the development of potencial vaccine Regulation of immunological mechanisms in health and disease:Development of new diagnostic and therapeutic approaches Interference of probiotics with factors determining pharmacokinetics of drugs
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	163
http://linked.open...iv/tvurceVysledku	Kopečný, Jan Mrázek, Jakub Tlaskalová-Hogenová, Helena Rossmann, Pavel Hudcovic, Tomáš Klimešová, Klára Kverka, Miloslav Zákostelská, Zuzana Hrnčíř, Tomáš Sokol, Dan Verdu, E.
http://linked.open...ain/vavai/riv/wos	000285922400013
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Genetic, functional and developmental potential of animal cells, tissues and organisms: their use in medicine, ecology and agriculture
issn	0009-9104
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1365-2249.2010.04286.x

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