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  • The maturation of vertebrate oocyte into haploid gamete, the egg, consists of two specialized asymmetric cell divisions with no intervening S-phase. Ran GTPase has an essential role in relaying the active role of chromosomes in their own segregation by the meiotic process. In addition to its conserved role as a key regulator of macromolecular transport between nucleus and cytoplasm, Ran has important functions during cell division, including in mitotic spindle assembly and in the assembly of nuclear envelope at the exit from mitosis. The cellular functions of Ran are mediated by RanGTP interactions with nuclear transport receptors (NTRs) related to importin b and depend on the existence of chromosome-centered RanGTP gradient. Live imaging with FRET biosensors indeed revealed the existence of RanGTP gradient throughout mouse oocyte maturation.
  • The maturation of vertebrate oocyte into haploid gamete, the egg, consists of two specialized asymmetric cell divisions with no intervening S-phase. Ran GTPase has an essential role in relaying the active role of chromosomes in their own segregation by the meiotic process. In addition to its conserved role as a key regulator of macromolecular transport between nucleus and cytoplasm, Ran has important functions during cell division, including in mitotic spindle assembly and in the assembly of nuclear envelope at the exit from mitosis. The cellular functions of Ran are mediated by RanGTP interactions with nuclear transport receptors (NTRs) related to importin b and depend on the existence of chromosome-centered RanGTP gradient. Live imaging with FRET biosensors indeed revealed the existence of RanGTP gradient throughout mouse oocyte maturation. (en)
Title
  • The Role of RanGTP Gradient in Vertebrate Oocyte Maturation
  • The Role of RanGTP Gradient in Vertebrate Oocyte Maturation (en)
skos:prefLabel
  • The Role of RanGTP Gradient in Vertebrate Oocyte Maturation
  • The Role of RanGTP Gradient in Vertebrate Oocyte Maturation (en)
skos:notation
  • RIV/67985904:_____/11:00360511!RIV12-AV0-67985904
http://linked.open...avai/riv/aktivita
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  • P(GC301/09/J036), P(ME08030), Z(AV0Z50450515)
http://linked.open...vai/riv/dodaniDat
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  • 227499
http://linked.open...ai/riv/idVysledku
  • RIV/67985904:_____/11:00360511
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  • RanGTP; Oocyte (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [16D87DA2DAD0]
http://linked.open...i/riv/mistoVydani
  • Heidelberg
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  • Results and Problems in Cell Differentiation
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  • Motlík, Jan
  • Kalab, P.
  • Šolc, Petr
http://linked.open...n/vavai/riv/zamer
number of pages
http://bibframe.org/vocab/doi
  • 10.1007/978-3-642-19065-0_12
http://purl.org/ne...btex#hasPublisher
  • Springer-Verlag
https://schema.org/isbn
  • 978-3-642-19065-0
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