About: Haplotype analysis of the interleukin-18 gene in Czech patients with allergic disorders

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The interleukin-18 (IL-18) gene on chromosome 11q22 has been suggested as a susceptibility factor for allergies. To test for a possible role of IL-18 polymorphisms in Czech population, case-control study including 958 subjects (633 allergic patients and 325 healthy controls) was performed. An allele-specific polymerase chain reaction was used to analyze variants at positions -607 C/A (rs1946518) and -137 G/C (rs187238) in the promoter region together with the polymerase chain reaction-restriction fragment length polymorphism method for the detection of polymorphism at position -140 C/G (previously -133 C/G, rs360721) in intron 1 of the IL-18 gene. The -1297 C/T (rs360719) polymorphism was genotyped by real-time-polymerase chain reaction, using a predevelopment TaqMan allele discrimination assay. There were no significant differences in distribution of alleles or genotypes in any of four single nucleotide polymorphisms in the IL-18 gene between controls and patients. The interleukin-18 (IL-18) gene on chromosome 11q22 has been suggested as a susceptibility factor for allergies. To test for a possible role of IL-18 polymorphisms in Czech population, case-control study including 958 subjects (633 allergic patients and 325 healthy controls) was performed. An allele-specific polymerase chain reaction was used to analyze variants at positions -607 C/A (rs1946518) and -137 G/C (rs187238) in the promoter region together with the polymerase chain reaction-restriction fragment length polymorphism method for the detection of polymorphism at position -140 C/G (previously -133 C/G, rs360721) in intron 1 of the IL-18 gene. The -1297 C/T (rs360719) polymorphism was genotyped by real-time-polymerase chain reaction, using a predevelopment TaqMan allele discrimination assay. There were no significant differences in distribution of alleles or genotypes in any of four single nucleotide polymorphisms in the IL-18 gene between controls and patients. (en)
Title	Haplotype analysis of the interleukin-18 gene in Czech patients with allergic disorders Haplotype analysis of the interleukin-18 gene in Czech patients with allergic disorders (en)
skos:prefLabel	Haplotype analysis of the interleukin-18 gene in Czech patients with allergic disorders Haplotype analysis of the interleukin-18 gene in Czech patients with allergic disorders (en)
skos:notation	RIV/67985904:_____/10:00360883!RIV12-AV0-67985904
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06060), Z(AV0Z50450515)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Bučková, Dana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	261189
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/10:00360883
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	allergic diseases; asthma; IL-18 (en)
http://linked.open.../riv/klicoveSlovo	allergic diseases asthma IL-18
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C2590F71451F]
http://linked.open...i/riv/nazevZdroje	Human Immunology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Increasing the efficacy of the diagnostics and treatment of gastro-esophageal reflux disease.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	71
http://linked.open...iv/tvurceVysledku	Hrdličková, B. Bučková, Dana Izakovic, V. Izakovičová-Hollá, L. Kindlová, D. Schüller, M. Vasku, A.
http://linked.open...ain/vavai/riv/wos	000278426100009
http://linked.open...n/vavai/riv/zamer	Genetic, functional and developmental potential of animal cells, tissues and organisms: their use in medicine, ecology and agriculture
issn	0198-8859
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.humimm.2010.03.004

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