About: Synthetic poly(amino acid) hydrogels with incorporated cell-adhesion peptides for tissue engineering

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About: Synthetic poly(amino acid) hydrogels with incorporated cell-adhesion peptides for tissue engineering Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Preparation of soft poly(amino acid) hydrogels containing biomimetic cell-adhesive peptides was investigated. Covalently crosslinked gels were formed by radical co-polymerization of methacryloylated macromonomer poly[N5-(2-hydroxyethyl)-L-glutamine-stat-L-alanine-stat-methacryloyllysine] with 2-hydroxyethyl methacrylate (HEMA) as minor co-monomer. Hydrogels carrying biomimetic peptides were prepared by using methacryloylated peptides, such as methacryloyl-GGGRGDSG-OH and methacryloyl-GGGYIGSR-OH, as additional monomers in the polymerization mixture. While unmodified hydrogels showed very low cell adhesion, due to their highly hydrophilic nature, the incorporation of adhesive peptides significantly improved the adhesion and viability of seeded cells. Preparation of soft poly(amino acid) hydrogels containing biomimetic cell-adhesive peptides was investigated. Covalently crosslinked gels were formed by radical co-polymerization of methacryloylated macromonomer poly[N5-(2-hydroxyethyl)-L-glutamine-stat-L-alanine-stat-methacryloyllysine] with 2-hydroxyethyl methacrylate (HEMA) as minor co-monomer. Hydrogels carrying biomimetic peptides were prepared by using methacryloylated peptides, such as methacryloyl-GGGRGDSG-OH and methacryloyl-GGGYIGSR-OH, as additional monomers in the polymerization mixture. While unmodified hydrogels showed very low cell adhesion, due to their highly hydrophilic nature, the incorporation of adhesive peptides significantly improved the adhesion and viability of seeded cells. (en)
Title	Synthetic poly(amino acid) hydrogels with incorporated cell-adhesion peptides for tissue engineering Synthetic poly(amino acid) hydrogels with incorporated cell-adhesion peptides for tissue engineering (en)
skos:prefLabel	Synthetic poly(amino acid) hydrogels with incorporated cell-adhesion peptides for tissue engineering Synthetic poly(amino acid) hydrogels with incorporated cell-adhesion peptides for tissue engineering (en)
skos:notation	RIV/67985904:_____/10:00345865!RIV11-MSM-67985904
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0538), P(KJB400500801), Z(AV0Z40500505), Z(AV0Z50450515)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Motlík, Jan Juhásová, Jana Vodička, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	291572
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/10:00345865
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	polyamino acid; hydrogel; porosity (en)
http://linked.open.../riv/klicoveSlovo	polyamino acid porosity hydrogel
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[36E77F2DA2AD]
http://linked.open...i/riv/nazevZdroje	Journal of Tissue Engineering and Regenerative Medicine
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Biodegradable hydrophilic materials for soft tissue regeneration Center for Cell Therapy and Tissue Repair
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Motlík, Jan Studenovská, Hana Vodička, Petr Rypáček, František Proks, Vladimír Hlučilová, Jana
http://linked.open...ain/vavai/riv/wos	000281152400005
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie Genetic, functional and developmental potential of animal cells, tissues and organisms: their use in medicine, ecology and agriculture
issn	1932-6254
number of pages	10 (xsd:int)

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