About: Proteome of leukaemic cells after cisplatin treatment - comparison of three independent analytical techniques

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Proteomic profiling of cancer cells was carried out with a view to addressing leukaemia and its treatment with a perspective towards novel diagnostic and/or treatment modalities. Earlier protein changes that precede the onset of apoptosis were studied using proteomic analysis of cells treated with anticancer drug cisplatin. To reliably quantify maximum number of proteins, combination of three proteomic techniques were used, namely 2-D electrophoresis, 2-D liquid chromatography and SILAC approach. The combination of several different methods was able to reveal and identify a large number of different proteins of interest. With such an approach we aim to extend our understanding of the on-going’ changes in CEM cell proteome induced by cisplatin treatment. Proteomic profiling of cancer cells was carried out with a view to addressing leukaemia and its treatment with a perspective towards novel diagnostic and/or treatment modalities. Earlier protein changes that precede the onset of apoptosis were studied using proteomic analysis of cells treated with anticancer drug cisplatin. To reliably quantify maximum number of proteins, combination of three proteomic techniques were used, namely 2-D electrophoresis, 2-D liquid chromatography and SILAC approach. The combination of several different methods was able to reveal and identify a large number of different proteins of interest. With such an approach we aim to extend our understanding of the on-going’ changes in CEM cell proteome induced by cisplatin treatment. (en)
Title	Proteome of leukaemic cells after cisplatin treatment - comparison of three independent analytical techniques Proteome of leukaemic cells after cisplatin treatment - comparison of three independent analytical techniques (en)
skos:prefLabel	Proteome of leukaemic cells after cisplatin treatment - comparison of three independent analytical techniques Proteome of leukaemic cells after cisplatin treatment - comparison of three independent analytical techniques (en)
skos:notation	RIV/67985904:_____/09:00338301!RIV10-MSM-67985904
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC07017), Z(AV0Z50200510), Z(AV0Z50450515)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kovářová, Hana Hrabáková, Rita Skalníková, Helena Tylečková, Jiřina
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	337276
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/09:00338301
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Proteomics; Cis-platin; Leukaemic cells (en)
http://linked.open.../riv/klicoveSlovo	Proteomics Leukaemic cells Cis-platin
http://linked.open...ontrolniKodProRIV	[E99232FA9D61]
http://linked.open...v/mistoKonaniAkce	Budapešť
http://linked.open...i/riv/mistoVydani	Budapest
http://linked.open...i/riv/nazevZdroje	3rd Central and Eastern Proteomics Conference, 2009
http://linked.open...in/vavai/riv/obor	FK
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Oncoproteomics Centre
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Man, Petr Novák, Petr Havlíček, Vladimír Hrabáková, Rita Kovářová, Hana Skalníková, Helena Pompach, Petr Strohalm, Martin Džubák, P. Hajdúch, M. Martinková, Jiřina
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2009-10-06 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Genetic, functional and developmental potential of animal cells, tissues and organisms: their use in medicine, ecology and agriculture
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Hungarian proteomic society
https://schema.org/isbn	978-963-9319-99-8

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