About: Multivariate statistical analysis for anti-cancer drug treatment evaluation

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of our study is to reveal molecular mechanisms of response to anti-cancer drugs at early time intervals to detect proteins that may be responsible for primary changes in the signalling networks and leading to irreversible anti-cancer processes. Leukaemic CEM cells were treated with various chemotherapeutic drugs. Evaluation of quantitative data from 2-D protein maps using multivariate statistical approach, principal component analysis, revealed that only about 2% of total variances represented differences that enabled grouping of drugs and their classification according to protein profiles. Drugs were clustered into groups independently of basic scheme of conventional chemotherapy agents indicating that there might be other unexplained mechanisms underlying the anti-cancer response and/or chemoresistance. The aim of our study is to reveal molecular mechanisms of response to anti-cancer drugs at early time intervals to detect proteins that may be responsible for primary changes in the signalling networks and leading to irreversible anti-cancer processes. Leukaemic CEM cells were treated with various chemotherapeutic drugs. Evaluation of quantitative data from 2-D protein maps using multivariate statistical approach, principal component analysis, revealed that only about 2% of total variances represented differences that enabled grouping of drugs and their classification according to protein profiles. Drugs were clustered into groups independently of basic scheme of conventional chemotherapy agents indicating that there might be other unexplained mechanisms underlying the anti-cancer response and/or chemoresistance. (en)
Title	Multivariate statistical analysis for anti-cancer drug treatment evaluation Multivariate statistical analysis for anti-cancer drug treatment evaluation (en)
skos:prefLabel	Multivariate statistical analysis for anti-cancer drug treatment evaluation Multivariate statistical analysis for anti-cancer drug treatment evaluation (en)
skos:notation	RIV/67985904:_____/09:00338291!RIV10-MSM-67985904
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC07017), Z(AV0Z50200510), Z(AV0Z50450515)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kovářová, Hana Hrabáková, Rita Skalníková, Helena Tylečková, Jiřina
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	328055
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/09:00338291
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Ovarian hyperstimulation syndrom; Follicular fluid; Biomarkers (en)
http://linked.open.../riv/klicoveSlovo	Follicular fluid Biomarkers Ovarian hyperstimulation syndrom
http://linked.open...ontrolniKodProRIV	[39E33375BB57]
http://linked.open...v/mistoKonaniAkce	Budapešť
http://linked.open...i/riv/mistoVydani	Budapešť
http://linked.open...i/riv/nazevZdroje	3rd Central and Eastern European Proteomics Conference
http://linked.open...in/vavai/riv/obor	FK
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Oncoproteomics Centre
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Novák, Petr Gadher, S. J. Hrabáková, Rita Kovářová, Hana Skalníková, Helena Hajduch, M. Džubák, P. Radová, L. Martinková, Jiřina Kollareddy, M. R.
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2009-10-06 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Genetic, functional and developmental potential of animal cells, tissues and organisms: their use in medicine, ecology and agriculture
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Hungarian Chemical Society
https://schema.org/isbn	978-963-9319-99-8

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