About: Targed neural stem cell differentiation and related cell based therapy in spinal cord injury

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About: Targed neural stem cell differentiation and related cell based therapy in spinal cord injury Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Transplantation of stem cells represents a unique approach to treat spinal trauma. To follow in vivo traumatic changes, the signalling proteins were studied in the rat spinal cord transsection. 80th motoneurons and sensory neurons were subjected to analysis. Computer modeling of protein changes indicates that downregulated proteins belong to oxidative stress response as well as cellular fate and organisation. Increase of proteins involved in genome maintenance was observed in ventral horns. Only marginal changes were found in the dorsal root ganglia. To characterise mechanisms governing differentiation we combined the porcine neural stem cells in vitro differentiation and complementary proteomic analyses. The stem cells exhibited high levels of GRK2 and several members of FAS pathway. Typical for differentiated neural cells were enhanced integrin, PDGF and MAP kinase signalling and heme-oxygenase 2. Characterisation of changes related to cell differentiation helps to define suitab Transplantation of stem cells represents a unique approach to treat spinal trauma. To follow in vivo traumatic changes, the signalling proteins were studied in the rat spinal cord transsection. 80th motoneurons and sensory neurons were subjected to analysis. Computer modeling of protein changes indicates that downregulated proteins belong to oxidative stress response as well as cellular fate and organisation. Increase of proteins involved in genome maintenance was observed in ventral horns. Only marginal changes were found in the dorsal root ganglia. To characterise mechanisms governing differentiation we combined the porcine neural stem cells in vitro differentiation and complementary proteomic analyses. The stem cells exhibited high levels of GRK2 and several members of FAS pathway. Typical for differentiated neural cells were enhanced integrin, PDGF and MAP kinase signalling and heme-oxygenase 2. Characterisation of changes related to cell differentiation helps to define suitab (en)
Title	Targed neural stem cell differentiation and related cell based therapy in spinal cord injury Targed neural stem cell differentiation and related cell based therapy in spinal cord injury (en)
skos:prefLabel	Targed neural stem cell differentiation and related cell based therapy in spinal cord injury Targed neural stem cell differentiation and related cell based therapy in spinal cord injury (en)
skos:notation	RIV/67985904:_____/09:00330776!RIV10-MSM-67985904
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0538), Z(AV0Z50200510), Z(AV0Z50450515)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Motlík, Jan Kovářová, Hana Skalníková, Helena Vodička, Petr
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	345373
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/09:00330776
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	stem cells; cell therapy; spinal cord injury (en)
http://linked.open.../riv/klicoveSlovo	spinal cord injury stem cells cell therapy
http://linked.open...ontrolniKodProRIV	[E54D15229606]
http://linked.open...v/mistoKonaniAkce	Budapešť
http://linked.open...i/riv/mistoVydani	Budapest
http://linked.open...i/riv/nazevZdroje	3rd Central and Eastern Proteomics Conference, 2009
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Cell Therapy and Tissue Repair
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Halada, Petr Motlík, Jan Vodička, Petr Gadher, S. J. Kovářová, Hana Skalníková, Helena Maršala, M.
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2009-10-06 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Genetic, functional and developmental potential of animal cells, tissues and organisms: their use in medicine, ecology and agriculture
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Hungarian proteomic society
https://schema.org/isbn	978-963-9319-99-8

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