About: Response of Ependymal Progenitors to Spinal Cord Injury or Enhanced Physical Activity in Adult Rat

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ependymal cells (EC) in the spinal cord central canal (CC) are believed to be responsible for the postnatal neurogenesis following pathological or stimulatory conditions. In this study, we have analyzed the proliferation of the CC ependymal progenitors in adult rats processed to compression SCI or enhanced physical activity. To label dividing cells, a single daily injection of Bromo-deoxyuridine (BrdU) was administered over a 14-day-survival period. Systematic quantification of BrdU-positive ependymal progenitors was performed by using stereological principles of systematic, random sampling, and optical Dissector software. The number of proliferating BrdUlabeled EC increased gradually with the time of survival after both paradigms, spinal cord injury, or increased physical activity. In the spinal cord injury group, we have found 4.9-fold (4 days), 7.1-fold (7 days), 4.9-fold (10 days), and 5.6-fold (14 days) increase of proliferating EC in the rostro-caudal regions, 4 mm away from the epicenter. In... Ependymal cells (EC) in the spinal cord central canal (CC) are believed to be responsible for the postnatal neurogenesis following pathological or stimulatory conditions. In this study, we have analyzed the proliferation of the CC ependymal progenitors in adult rats processed to compression SCI or enhanced physical activity. To label dividing cells, a single daily injection of Bromo-deoxyuridine (BrdU) was administered over a 14-day-survival period. Systematic quantification of BrdU-positive ependymal progenitors was performed by using stereological principles of systematic, random sampling, and optical Dissector software. The number of proliferating BrdUlabeled EC increased gradually with the time of survival after both paradigms, spinal cord injury, or increased physical activity. In the spinal cord injury group, we have found 4.9-fold (4 days), 7.1-fold (7 days), 4.9-fold (10 days), and 5.6-fold (14 days) increase of proliferating EC in the rostro-caudal regions, 4 mm away from the epicenter. In... (en)
Title	Response of Ependymal Progenitors to Spinal Cord Injury or Enhanced Physical Activity in Adult Rat Response of Ependymal Progenitors to Spinal Cord Injury or Enhanced Physical Activity in Adult Rat (en)
skos:prefLabel	Response of Ependymal Progenitors to Spinal Cord Injury or Enhanced Physical Activity in Adult Rat Response of Ependymal Progenitors to Spinal Cord Injury or Enhanced Physical Activity in Adult Rat (en)
skos:notation	RIV/67985904:_____/09:00328392!RIV10-MSM-67985904
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(MEB0808108), Z(AV0Z50450515)
http://linked.open...iv/cisloPeriodika	6-7
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Motlík, Jan Juhásová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	339172
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/09:00328392
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Spinal cord injury; Neural stem cells; BrdU (en)
http://linked.open.../riv/klicoveSlovo	BrdU Neural stem cells Spinal cord injury
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3E56EAA9200E]
http://linked.open...i/riv/nazevZdroje	Cellular and Molecular Neurobiology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Modulace regenerace poraněné míchy prostřednictvím neurálních progenitorů
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Motlík, Jan Novotná, I. Tomori, Z. Vanický, I. Čížková, D. Čížek, M. Hlučilová, Jana Nagyová, M. Radoňák, J. Slovinská, L. Mechirová, E. Sulla, I.
http://linked.open...ain/vavai/riv/wos	000268482300027
http://linked.open...n/vavai/riv/zamer	Genetic, functional and developmental potential of animal cells, tissues and organisms: their use in medicine, ecology and agriculture
issn	0272-4340
number of pages	15 (xsd:int)

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