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| rdf:type
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| Description
| - The isolation of neural stem cells from fetal and adult mammalian CNS and the demonstration of functional neurogenesis in adult CNS have offered perspectives for treatment of many devastating hereditary and acquired neurological diseases. Due to this enormous potential, neural stem cells are a subject of extensive molecular profiling studies with a search for new markers and regulatory pathways governing their self-renewal as opposed to differentiation. Additionally, neurons and glial cells have been obtained from embryonic stem cells and mesenchymal stem cells, and proteins associated with the differentiation process have been characterized to a certain degree with a view to further investigations. This review summarizes recent findings relevant to the proteomics of neural stem cells and discusses major proteins significantly regulated during neural stem cell differentiation with a view to their future use in cell-based regenerative and reparative therapy.
- The isolation of neural stem cells from fetal and adult mammalian CNS and the demonstration of functional neurogenesis in adult CNS have offered perspectives for treatment of many devastating hereditary and acquired neurological diseases. Due to this enormous potential, neural stem cells are a subject of extensive molecular profiling studies with a search for new markers and regulatory pathways governing their self-renewal as opposed to differentiation. Additionally, neurons and glial cells have been obtained from embryonic stem cells and mesenchymal stem cells, and proteins associated with the differentiation process have been characterized to a certain degree with a view to further investigations. This review summarizes recent findings relevant to the proteomics of neural stem cells and discusses major proteins significantly regulated during neural stem cell differentiation with a view to their future use in cell-based regenerative and reparative therapy. (en)
- Objev tvorby nových neuronů v CNS dospělých savců a možnost izolace nervových kmenových buněk z mozku a míchy vzbudila velký zájem a naději pro léčbu dědičných i získaných neurologikých chorob. Vzhledem k tomuto obrovskému potenciálnímu terapeutickému využití jsou nerv. kmen. buňky předmětem intenzivního výzkumu na molekulární úrovni s cílem najít nové markery a regulační dráhy, které řídí jejich sebeobnovu a diferenciaci do nervových buněk. Dosavadní studie proteomu však reprezentují pouze počáteční kroky k porozumění biologii nerv. kmen. buněk. V tomto článku shrnujeme dosavadní poznatky získané studiem proteomu nerv. kmen. buněk a diskutujeme hlavní proteiny, jejichž hladina se významně mění během diferenciace, s ohledem na budoucí použití těchto buněk v bunečných regeneračních a reparačních terapiích. (cs)
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| Title
| - Proteomics of neural stem cells
- Proteomics of neural stem cells (en)
- Proteomika nervových kmenových buněk (cs)
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| skos:prefLabel
| - Proteomics of neural stem cells
- Proteomics of neural stem cells (en)
- Proteomika nervových kmenových buněk (cs)
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| skos:notation
| - RIV/67985904:_____/08:00308682!RIV08-AV0-67985904
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(1M0538), Z(AV0Z50450515)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/67985904:_____/08:00308682
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - cell-based regnerative and reparative therapy; conditioned media; differentiation (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Expert Review of Proteomics
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Vodička, Petr
- Gadher, S. J.
- Kovářová, Hana
- Skalníková, Helena
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| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
| |
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