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| rdf:type
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| Description
| - The changes in mammary, uterine and seminal vesicle growth were intended to identify the in vivo activity of estrogen antagonists. Using the combinations of hormone agonist and antagonist, we tested and compared four models systems, the young intact and adult gonadectomized male and female mice. Steroidal antiestrogen (ICI) always behaved as an antiestrogen: ICI alone or in combination with estradiol (E) or progesterone (Prog) decreased mammary and uterine growth in prepubertal and adult ovariectomized (OV-X) females and decreased mammary growth in prepubertal and adult castrated males treated with E. In prepubertal males ICI alone or in combination with Prog or E also increased seminal vesicle weights. Nonsteroidal antiestrogen EM-800 (EM) alone had no effect on mammary and uterine growth in prepubertal females, and in adult OV-X females uterine growth was even stimulated by EM alone, and a combination of EM plus Prog stimulated not only uterine growth but also mam,ary growth.
- The changes in mammary, uterine and seminal vesicle growth were intended to identify the in vivo activity of estrogen antagonists. Using the combinations of hormone agonist and antagonist, we tested and compared four models systems, the young intact and adult gonadectomized male and female mice. Steroidal antiestrogen (ICI) always behaved as an antiestrogen: ICI alone or in combination with estradiol (E) or progesterone (Prog) decreased mammary and uterine growth in prepubertal and adult ovariectomized (OV-X) females and decreased mammary growth in prepubertal and adult castrated males treated with E. In prepubertal males ICI alone or in combination with Prog or E also increased seminal vesicle weights. Nonsteroidal antiestrogen EM-800 (EM) alone had no effect on mammary and uterine growth in prepubertal females, and in adult OV-X females uterine growth was even stimulated by EM alone, and a combination of EM plus Prog stimulated not only uterine growth but also mam,ary growth. (en)
- Změny v růstu mléčné žlázy, dělohy a semenných váčků byly použity k identifikaci aktivit antagonistů estrogenů v podmínkách in vivo. Na 4 modelech (mladé intaktní a dospělé gonadektomované samice a samci myší) byly testovány účinky samotných antagonistů a kombinací antagonistů s estradiolem (E) nebo progesteronem (Prog). ICI 182 780 (ICI) se vždy choval jako antiestrogen: růst mléčné žlázy intaktních prepubertálních a dospělých ovariektomovaných (OV-X) samic snížil ICI jak samotný, tak v kombinaci s E nebo Prog. Podobně ICI snížil E stimulovaný růst mléčné žlázy intaktních prepubertálních a dospělých kastrovaných samců. Samotný ICI snížil růst dělohy u prepubertálních samic a ICI v kombinaci s Prog nebo E snížil růst dělohy jak u prepubertálních, tak u dospělých OV-X samic. Hmotnost semenných váčků mladých prepubertálních samců ICI zvýšil a to jak samotný, tak v kombinaci s E nebo Prog. Naproti tomu samotný EM-800 neměl žádný účinek na růst mléčné žlázy i dělohy prepubertálních samic. (cs)
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| Title
| - Contrasting ability of steroidal (ICI 182 780) and non-steroidal (EM-800) antiestrogens to inhibit reproductive organ growth in male and female mice
- Contrasting ability of steroidal (ICI 182 780) and non-steroidal (EM-800) antiestrogens to inhibit reproductive organ growth in male and female mice (en)
- Rozdílné schopnosti steroidního (ICI 182 780) a nesteroidního (EM-800) antiestrogenu inhibitovat růst reprodukčních orgánů samců a samic myší (cs)
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| skos:prefLabel
| - Contrasting ability of steroidal (ICI 182 780) and non-steroidal (EM-800) antiestrogens to inhibit reproductive organ growth in male and female mice
- Contrasting ability of steroidal (ICI 182 780) and non-steroidal (EM-800) antiestrogens to inhibit reproductive organ growth in male and female mice (en)
- Rozdílné schopnosti steroidního (ICI 182 780) a nesteroidního (EM-800) antiestrogenu inhibitovat růst reprodukčních orgánů samců a samic myší (cs)
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| skos:notation
| - RIV/67985904:_____/05:00029376!RIV06-AV0-67985904
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(IBS5045302), Z(AV0Z50450515)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/67985904:_____/05:00029376
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - antiestrogen; growth; mammary gland (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Köhlerová, Eva
- Škarda, Josef
- Kotanová, Jana
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| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
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