About: The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells.

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About: The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The presence of truncated form of cyclin A2 has been reported in various murine cell lines and tissues. In this paper it was shown that while undifferentiated proliferating mouse embryonic stem cells express low levels of this truncated cyclin A2, cells that are induced to differentiate remarkably increase its synthesis. Importantly, the expression pattern of truncated cyclin A2 was the same in p27 -/- ES cells as in the wild-type ES cells. Thus, it suggests that p27 is not necessary for the proteolytic cleavage of cyclin A2 and that this post-translational modification correlates with differentiation. The presence of truncated form of cyclin A2 has been reported in various murine cell lines and tissues. In this paper it was shown that while undifferentiated proliferating mouse embryonic stem cells express low levels of this truncated cyclin A2, cells that are induced to differentiate remarkably increase its synthesis. Importantly, the expression pattern of truncated cyclin A2 was the same in p27 -/- ES cells as in the wild-type ES cells. Thus, it suggests that p27 is not necessary for the proteolytic cleavage of cyclin A2 and that this post-translational modification correlates with differentiation. (en)
Title	The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells. The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells. (en)
skos:prefLabel	The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells. The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells. (en)
skos:notation	RIV/67985904:_____/03:21033079!RIV/2004/GA0/A21004/N
http://linked.open.../vavai/riv/strany	825;830
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA523/00/0780), P(LN00A065), Z(AV0Z5039906), Z(AV0Z5045916)
http://linked.open...iv/cisloPeriodika	N/A
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Motlík, Jan Kubelka, Michal Anger, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	598808
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/03:21033079
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mouse embryonic stem cell (en)
http://linked.open.../riv/klicoveSlovo	mouse embryonic stem cell
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[30118418C2CD]
http://linked.open...i/riv/nazevZdroje	Biochemical and Biophysical Research Communications
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Cell Therapy and Tissue Repair Zygotic activation of cyclin genes with accent to cyclin A1 in the mouse
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	302
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Dvořák, Petr Hampl, Aleš Motlík, Jan Anger, Martin Kubelka, Michal Carrington, M. Jirmanová, L.
http://linked.open...n/vavai/riv/zamer	Základní výzkum genetických struktur, fyziologických funkcí a vývojové biologie obratlovců se zaměřením na biomedicínsky, hospodářsky i jinak významné druhy The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy
issn	0006-291X
number of pages	6 (xsd:int)

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