About: Butyrolactone I Reversibly Inhibits Meiotic Maturation of Bovine Oocytes, Without Influencing Chromosome Condensation Activity.

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About: Butyrolactone I Reversibly Inhibits Meiotic Maturation of Bovine Oocytes, Without Influencing Chromosome Condensation Activity. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this study, butyrolactone I (BL I), a potent and specific inhibitor of cyclin-dependent kinases, was shown to block germinal vesicle (CV) breakdown (GVBD) in bovine oocytes in a concentration-dependent manner; GVBD was almost totally inhibited over the course of 24-48 h of culture when 100 mu M BL I was included in tissue culture medium 199 containing either polyvinyl alcohol or BSA. Correlated with this inhibition was the failure of either p34(cdc2) kinase or mitogen-activated protein (MAP) kinase to become activated, and it was unlikely that BL I directly inhibited MAP kinase, since 100 mu M BL I did not inhibit MAP kinase activity present in extracts obtained from metaphase II-arrested bovine eggs that possess high levels of MAP kinase activity. Nevertheless, the formation of highly condensed bivalents was observed in 78% of the BL I-treated GV-intact oocytes, This result suggests that chromosome condensation during first meiosis in bovine oocytes does not require the activity of either p34cdc2 In this study, butyrolactone I (BL I), a potent and specific inhibitor of cyclin-dependent kinases, was shown to block germinal vesicle (CV) breakdown (GVBD) in bovine oocytes in a concentration-dependent manner; GVBD was almost totally inhibited over the course of 24-48 h of culture when 100 mu M BL I was included in tissue culture medium 199 containing either polyvinyl alcohol or BSA. Correlated with this inhibition was the failure of either p34(cdc2) kinase or mitogen-activated protein (MAP) kinase to become activated, and it was unlikely that BL I directly inhibited MAP kinase, since 100 mu M BL I did not inhibit MAP kinase activity present in extracts obtained from metaphase II-arrested bovine eggs that possess high levels of MAP kinase activity. Nevertheless, the formation of highly condensed bivalents was observed in 78% of the BL I-treated GV-intact oocytes, This result suggests that chromosome condensation during first meiosis in bovine oocytes does not require the activity of either p34cdc2 (en)
Title	Butyrolactone I Reversibly Inhibits Meiotic Maturation of Bovine Oocytes, Without Influencing Chromosome Condensation Activity. Butyrolactone I Reversibly Inhibits Meiotic Maturation of Bovine Oocytes, Without Influencing Chromosome Condensation Activity. (en)
skos:prefLabel	Butyrolactone I Reversibly Inhibits Meiotic Maturation of Bovine Oocytes, Without Influencing Chromosome Condensation Activity. Butyrolactone I Reversibly Inhibits Meiotic Maturation of Bovine Oocytes, Without Influencing Chromosome Condensation Activity. (en)
skos:notation	RIV/67985904:_____/00:21003004!RIV/2003/AV0/A21003/N
http://linked.open.../vavai/riv/strany	292;302
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GV524/96/K162), P(KSK2038602), Z(AV0Z5045916)
http://linked.open...iv/cisloPeriodika	N/A
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Motlík, Jan Kubelka, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	706002
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/00:21003004
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N/A (en)
http://linked.open.../riv/klicoveSlovo	N/A
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[083B513F35CE]
http://linked.open...i/riv/nazevZdroje	Biology of Reproduction
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Cellular and molecular basis of oogenesis fertilization and embryonic development in mammals Inter- and intracellular signal systems
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	62
http://linked.open...iv/tvurceVysledku	Motlík, Jan Kubelka, Michal Schultz, R. M.
http://linked.open...n/vavai/riv/zamer	Základní výzkum genetických struktur, fyziologických funkcí a vývojové biologie obratlovců se zaměřením na biomedicínsky, hospodářsky i jinak významné druhy
issn	0006-3363
number of pages	11 (xsd:int)

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