About: Molecularly Imprinted Polymer Waveguides for Direct Optical Detection of Low-Molecular-Weight Analytes

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About: Molecularly Imprinted Polymer Waveguides for Direct Optical Detection of Low-Molecular-Weight Analytes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	New composite layer architecture of 3D hydrogel polymer network that is loaded with molecularly imprinted polymer nanoparticles (nanoMIP) is reported for direct optical detection of low-molecular-weight compounds. This composite layer is attached to the metallic surface of a surface plasmon resonance (SPR) sensor in order to simultaneously serve as an optical waveguide and large capacity binding-matrix for imprinted target analyte. Optical waveguide spectroscopy (OWS) is used as a label-free readout method allowing direct measurement of refractive index changes that are associated with molecular binding events inside the matrix. This approach is implemented by using a photocrosslinkable poly(N-isopropylacrylamide)-based hydrogel and poly[(ethylene glycol dimethylacrylate)-(methacrylic acid)] nanoparticles that are imprinted with L-Boc-phenylalanine-anilide (L-BFA, molecular weight 353 g mol(-1)). Titration experiments with the specific target and other structurally similar reference compounds show good specifi city and limit of detection for target L-BFA as low as 2 x 10(-6) M New composite layer architecture of 3D hydrogel polymer network that is loaded with molecularly imprinted polymer nanoparticles (nanoMIP) is reported for direct optical detection of low-molecular-weight compounds. This composite layer is attached to the metallic surface of a surface plasmon resonance (SPR) sensor in order to simultaneously serve as an optical waveguide and large capacity binding-matrix for imprinted target analyte. Optical waveguide spectroscopy (OWS) is used as a label-free readout method allowing direct measurement of refractive index changes that are associated with molecular binding events inside the matrix. This approach is implemented by using a photocrosslinkable poly(N-isopropylacrylamide)-based hydrogel and poly[(ethylene glycol dimethylacrylate)-(methacrylic acid)] nanoparticles that are imprinted with L-Boc-phenylalanine-anilide (L-BFA, molecular weight 353 g mol(-1)). Titration experiments with the specific target and other structurally similar reference compounds show good specifi city and limit of detection for target L-BFA as low as 2 x 10(-6) M (en)
Title	Molecularly Imprinted Polymer Waveguides for Direct Optical Detection of Low-Molecular-Weight Analytes Molecularly Imprinted Polymer Waveguides for Direct Optical Detection of Low-Molecular-Weight Analytes (en)
skos:prefLabel	Molecularly Imprinted Polymer Waveguides for Direct Optical Detection of Low-Molecular-Weight Analytes Molecularly Imprinted Polymer Waveguides for Direct Optical Detection of Low-Molecular-Weight Analytes (en)
skos:notation	RIV/67985882:_____/14:00441142!RIV15-GA0-67985882
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GBP205/12/G118)
http://linked.open...iv/cisloPeriodika	23
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Homola, Jiří Hegnerová, Kateřina Vala, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav fotoniky a elektroniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	30314
http://linked.open...ai/riv/idVysledku	RIV/67985882:_____/14:00441142
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Label-free biosensors; Molecularly imprinted polymers; Hydrogels (en)
http://linked.open.../riv/klicoveSlovo	Label-free biosensors Molecularly imprinted polymers Hydrogels
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[6E3CF16D6F03]
http://linked.open...i/riv/nazevZdroje	Macromolecular Chemistry and Physics
http://linked.open...in/vavai/riv/obor	JA
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Nanobiophotonics for future health care
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	215
http://linked.open...iv/tvurceVysledku	Homola, Jiří Dostálek, J. Vala, Milan Sharma, N. Knoll, W. Bach, M. Jonas, U. Mrkvová, Kateřina Petri, C. Tovar, G.
http://linked.open...ain/vavai/riv/wos	000345966900002
issn	1022-1352
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/macp.201400260

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