About: Optimization of the High-Shear Wet Granulation Wetting Process Using Fuzzy Logic Modeling

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A fuzzy model has been developed for the optimization of high-shear wet granulation wetting on a plant scale depending on the characteristics of pharmaceutical active substance particles. The model optimized on the basis of experimental data involves a set of rules obtained from expert knowledge and full-scale process data. The skewness coefficient of particle size distribution and the tapped density of the granulated mixture were chosen as the model input variables. The output of the fuzzy ruled system is the optimal quantity of wetting liquid. In comparison to manufacturing practice, a very strong sensitivity of the optimal quantity of the added wetting liquid to the size and shape of the active substance particles has been identified by fuzzy modeling. A fuzzy model has been developed for the optimization of high-shear wet granulation wetting on a plant scale depending on the characteristics of pharmaceutical active substance particles. The model optimized on the basis of experimental data involves a set of rules obtained from expert knowledge and full-scale process data. The skewness coefficient of particle size distribution and the tapped density of the granulated mixture were chosen as the model input variables. The output of the fuzzy ruled system is the optimal quantity of wetting liquid. In comparison to manufacturing practice, a very strong sensitivity of the optimal quantity of the added wetting liquid to the size and shape of the active substance particles has been identified by fuzzy modeling. (en) Byl vyvinut fuzzy model pro optimalizaci výrobního procesu vlhké granulace, založeného na charakteristikách částic aktivní farmaceutické substance. Model vychází z experimentálních dat a expertních znalostí průmyslového procesu. Parametry modelu jsou charakteristiky distribuce velikosti částic a setřesná hustota granulované směsi. Výstupem modelu je optimální množství vlhčiva, které koresponduje s velikostí a tvarem částic granulované substance. (cs)
Title	Optimization of the High-Shear Wet Granulation Wetting Process Using Fuzzy Logic Modeling Optimalizace procesu vlké granulace s použitím fuzzy-logického modelování (cs) Optimization of the High-Shear Wet Granulation Wetting Process Using Fuzzy Logic Modeling (en)
skos:prefLabel	Optimization of the High-Shear Wet Granulation Wetting Process Using Fuzzy Logic Modeling Optimalizace procesu vlké granulace s použitím fuzzy-logického modelování (cs) Optimization of the High-Shear Wet Granulation Wetting Process Using Fuzzy Logic Modeling (en)
skos:notation	RIV/67985858:_____/07:00099738!RIV08-AV0-67985858
http://linked.open.../vavai/riv/strany	345;352
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(AV0Z40720504), Z(MSM6046137301), Z(MSM6046137306)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Hanika, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav chemických procesů AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	439905
http://linked.open...ai/riv/idVysledku	RIV/67985858:_____/07:00099738
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	fuzzy logic; mathematical model; granulation (en)
http://linked.open.../riv/klicoveSlovo	fuzzy logic granulation mathematical model
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[28A69F23E167]
http://linked.open...i/riv/nazevZdroje	Pharmaceutical Development and Technology
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Hanika, Jiří Bělohlav, Z. Durdil, P. Kalčíková, J. Tomášek, V. Palatová, M. Břenková, L.
http://linked.open...n/vavai/riv/zamer	Catalytic processes in chemistry and chemical technology Investigation of multiphase reacting systems for the design of processes important in synthesis and preparation of novel materials, in energy production and in environmental protection Reakčně-transportní chemicko-inženýrské systémy a jejich dynamické chování, modelování a řízení chemických a biotechnologických procesů
issn	1083-7450
number of pages	8 (xsd:int)

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