About: Direct comparison of health effects by dietary polyphenols at equimolar doses in wildtype moderate high-fat fed C57BL/6JOlaHsd mice

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About: Direct comparison of health effects by dietary polyphenols at equimolar doses in wildtype moderate high-fat fed C57BL/6JOlaHsd mice Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We performed a systematic phenotypic evaluation of the effects of selected polyphenols (Epigallocatechin-gallate, quercetin, and resveratrol) in wildtype C57BL/6JOlaHsd mice fed high fat diet for 12 weeks. Results showed that these polyphenols were present in circulation, but did not induce beneficial health effects as analyzed by oral glucose tolerance testing or serum adipokines and CVD-markers such as vascular adhesion molecules. Remarkably, transcriptomics of white adipose tissue showed overlapping sets of significantly differential transcript levels between these polyphenols; AMPK and Notch signaling were affected by these polyphenols. However, mitochondrial processes and mitochondrial density in this tissue did not differ between the polyphenols, which suggested that there was no direct effect on adipose tissue We performed a systematic phenotypic evaluation of the effects of selected polyphenols (Epigallocatechin-gallate, quercetin, and resveratrol) in wildtype C57BL/6JOlaHsd mice fed high fat diet for 12 weeks. Results showed that these polyphenols were present in circulation, but did not induce beneficial health effects as analyzed by oral glucose tolerance testing or serum adipokines and CVD-markers such as vascular adhesion molecules. Remarkably, transcriptomics of white adipose tissue showed overlapping sets of significantly differential transcript levels between these polyphenols; AMPK and Notch signaling were affected by these polyphenols. However, mitochondrial processes and mitochondrial density in this tissue did not differ between the polyphenols, which suggested that there was no direct effect on adipose tissue (en)
Title	Direct comparison of health effects by dietary polyphenols at equimolar doses in wildtype moderate high-fat fed C57BL/6JOlaHsd mice Direct comparison of health effects by dietary polyphenols at equimolar doses in wildtype moderate high-fat fed C57BL/6JOlaHsd mice (en)
skos:prefLabel	Direct comparison of health effects by dietary polyphenols at equimolar doses in wildtype moderate high-fat fed C57BL/6JOlaHsd mice Direct comparison of health effects by dietary polyphenols at equimolar doses in wildtype moderate high-fat fed C57BL/6JOlaHsd mice (en)
skos:notation	RIV/67985823:_____/14:00435721!RIV15-GA0-67985823
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(7E10059), P(GA13-00871S)
http://linked.open...iv/cisloPeriodika	part A
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Kopecký, Jan Janovská, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	11637
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/14:00435721
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	polyphenols; intervention; adipokines; adipose tissue; transcriptomics (en)
http://linked.open.../riv/klicoveSlovo	transcriptomics adipokines adipose tissue intervention polyphenols
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E24B8C93704E]
http://linked.open...i/riv/nazevZdroje	Food Research International
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomarkets of Robustness of Metabolic - Hoemostasis for nutrigenomics - derived Health claims made on food Enhancing energy expenditure in white adipose tissue by combination treatments using n-3 fatty acids, resveratrol and calorie restriction
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	65
http://linked.open...iv/tvurceVysledku	Kopecký, Jan Janovská, Petra Hoevenaars, F.P.M. Keijer, J. van Schothorst, E. M. Bunschoten, A. Hollman, P. C. H. Venema, D. van der Stelt, I.
http://linked.open...ain/vavai/riv/wos	000347756000013
issn	0963-9969
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.foodres.2014.03.050

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