About: ROS generation and multiple forms of mammalian mitochondrial glycerol-3-phosphate dehydrogenase

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH) and succinate dehydrogenase (SDH) are important source of reactive oxygen species (ROS), but the mechanism of their production is still poorly understood. In this study we demonstrate two distinct mechanisms, with flavin being the most likely source of electron leak in SDH and coenzyme Q site in mGPDH. Furthermore, mGPDH was found to associate into homooligomers and supercomplexes capable to produce ROS similarly as the isolated enzyme itself Mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH) and succinate dehydrogenase (SDH) are important source of reactive oxygen species (ROS), but the mechanism of their production is still poorly understood. In this study we demonstrate two distinct mechanisms, with flavin being the most likely source of electron leak in SDH and coenzyme Q site in mGPDH. Furthermore, mGPDH was found to associate into homooligomers and supercomplexes capable to produce ROS similarly as the isolated enzyme itself (en)
Title	ROS generation and multiple forms of mammalian mitochondrial glycerol-3-phosphate dehydrogenase ROS generation and multiple forms of mammalian mitochondrial glycerol-3-phosphate dehydrogenase (en)
skos:prefLabel	ROS generation and multiple forms of mammalian mitochondrial glycerol-3-phosphate dehydrogenase ROS generation and multiple forms of mammalian mitochondrial glycerol-3-phosphate dehydrogenase (en)
skos:notation	RIV/67985823:_____/14:00428164!RIV15-GA0-67985823
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GPP303/10/P227), P(LL1204)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Holzerová, Eliška Houštěk, Josef Drahota, Zdeněk Vrbacký, Marek Mráček, Tomáš Ješina, Pavel Kovářová, Nikola
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	43285
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/14:00428164
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mitochondrial glycerol-3-phosphate dehydrogenase; ROS production; supercomplex; in-gel ROS detection (en)
http://linked.open.../riv/klicoveSlovo	in-gel ROS detection supercomplex mitochondrial glycerol-3-phosphate dehydrogenase ROS production
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[DEFEED7F3745]
http://linked.open...i/riv/nazevZdroje	Biochimica Et Biophysica Acta-Bioenergetics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Supramolecular assemblies in structural organization of inner mitochondrial membrane Genetic analysis of mitochondrial proteome: Integration of mitochondrial-nuclear epistasis with disease phenotypes in the rat
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	1837
http://linked.open...iv/tvurceVysledku	Drahota, Zdeněk Houštěk, Josef Kovářová, Nikola Vrbacký, Marek Ješina, Pavel Mráček, Tomáš Holzerová, Eliška
http://linked.open...ain/vavai/riv/wos	000328724800009
issn	0005-2728
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bbabio.2013.08.007

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