About: Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful?

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About: Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful? Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Gain-of-function (GOF) mutations in ion channels are rare events, which lead to increased agonist sensitivity or altered gating properties, and may render the channel constitutively active. Here we give an overview of some GOF mutants in polymodal ion channels specifically involved in transduction of painful stimuli – TRPV1 and TRPA1, which are scrutinized by scientists due to their important role in development of some pathological pain states Gain-of-function (GOF) mutations in ion channels are rare events, which lead to increased agonist sensitivity or altered gating properties, and may render the channel constitutively active. Here we give an overview of some GOF mutants in polymodal ion channels specifically involved in transduction of painful stimuli – TRPV1 and TRPA1, which are scrutinized by scientists due to their important role in development of some pathological pain states (en)
Title	Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful? Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful? (en)
skos:prefLabel	Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful? Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful? (en)
skos:notation	RIV/67985823:_____/14:00428039!RIV15-GA0-67985823
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GA305/09/0081), P(GBP304/12/G069)
http://linked.open...iv/cisloPeriodika	Suppl.1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Dittert, Ivan Chvojka, Štěpán Maršáková, Lenka Touška, Filip Vlachová, Viktorie Boukalová, Štěpána Surá, Lucie Hynková, Anna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	17889
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/14:00428039
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	transient receptor potential; ion channel; mutagenesis; vanilloid receptor; gating (en)
http://linked.open.../riv/klicoveSlovo	gating mutagenesis transient receptor potential vanilloid receptor ion channel
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[C9FDF1486FE4]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Project of excellence in the field of neuroscience Activation and regulation mechanisms of nociceptor-specific transient receptor potential channels: physiological role in acute and chronic pain
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	63
http://linked.open...iv/tvurceVysledku	Maršáková, Lenka Touška, Filip Vlachová, Viktorie Hynková, Anna Surá, Lucie Boukalová, Štěpána Dittert, Ivan Chvojka, Štěpán
http://linked.open...ain/vavai/riv/wos	000332073100017
issn	0862-8408
number of pages	9 (xsd:int)

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