About: Long-Term Activation upon Brief Exposure to Xanomleline Is Unique to M1 and M4 Subtypes of Muscarinic Acetylcholine Receptors     Goto   Sponge   NotDistinct   Permalink

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Description
  • Long-term receptor activation by xanomeline takes place in full only at M1 and M4 muscarinic receptors. Xanomeline displays higher efficacy at M1 and M4 receptors in primary phasic intracellular calcium release. These findings suggest the existence of particular activation mechanisms specific to these two receptor subtypes
  • Long-term receptor activation by xanomeline takes place in full only at M1 and M4 muscarinic receptors. Xanomeline displays higher efficacy at M1 and M4 receptors in primary phasic intracellular calcium release. These findings suggest the existence of particular activation mechanisms specific to these two receptor subtypes (en)
Title
  • Long-Term Activation upon Brief Exposure to Xanomleline Is Unique to M1 and M4 Subtypes of Muscarinic Acetylcholine Receptors
  • Long-Term Activation upon Brief Exposure to Xanomleline Is Unique to M1 and M4 Subtypes of Muscarinic Acetylcholine Receptors (en)
skos:prefLabel
  • Long-Term Activation upon Brief Exposure to Xanomleline Is Unique to M1 and M4 Subtypes of Muscarinic Acetylcholine Receptors
  • Long-Term Activation upon Brief Exposure to Xanomleline Is Unique to M1 and M4 Subtypes of Muscarinic Acetylcholine Receptors (en)
skos:notation
  • RIV/67985823:_____/14:00427640!RIV15-GA0-67985823
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(GA305/09/0681), P(GAP304/12/0259), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
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  • 26573
http://linked.open...ai/riv/idVysledku
  • RIV/67985823:_____/14:00427640
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • muscarinic receptors; functional selectivity; xanomeline (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [D577DE167D66]
http://linked.open...i/riv/nazevZdroje
  • PLoS ONE
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http://linked.open...v/svazekPeriodika
  • 9
http://linked.open...iv/tvurceVysledku
  • Doležal, Vladimír
  • El-Fakahany, E. E.
  • Jakubík, Jan
  • Šantrůčková, Eva
http://linked.open...ain/vavai/riv/wos
  • 000331706700094
http://linked.open...n/vavai/riv/zamer
issn
  • 1932-6203
number of pages
http://bibframe.org/vocab/doi
  • 10.1371/journal.pone.0088910
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