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rdf:type
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Description
| - GABAB-R1a, GABAB-R1b, GABAB-R2, Gi1/Gi2alpha, Gi3alpha, Goalpha, Gzalpha and Gbeta subunit protein content was determined by quantitative immunoblotting in PM isolated from brain cortex of rats of different ages: between postnatal day1 (PD1) and 90 (PD90). PM density of GABAB-R1alpha, GABAB-R2, Gi1/Gi2alpha, Gi3alpha, Goalpha, Gzalpha and Gbeta was high at birth. The intensity of GABAB-R1a and GABAB-R2 subunits signal decreased between the birth and PD15: to 55 % (R1a, **) and 51 % (R2, **), respectively. Contrarily, PM level of the cognate G-proteins Gi1/Gi2alpha, Gi3alpha, Goalpha, Gzalpha and Gbeta was unchanged in the course of the whole postnatal period of brain cortex development. Maturation of GABAB-R cascade was substantially different from ontogenetic profile of Na, K-ATPase, which was low at birth and increased between the birth and PD25. In adult rats, membrane content of Na, K-ATPase was 3-times higher than around the birth
- GABAB-R1a, GABAB-R1b, GABAB-R2, Gi1/Gi2alpha, Gi3alpha, Goalpha, Gzalpha and Gbeta subunit protein content was determined by quantitative immunoblotting in PM isolated from brain cortex of rats of different ages: between postnatal day1 (PD1) and 90 (PD90). PM density of GABAB-R1alpha, GABAB-R2, Gi1/Gi2alpha, Gi3alpha, Goalpha, Gzalpha and Gbeta was high at birth. The intensity of GABAB-R1a and GABAB-R2 subunits signal decreased between the birth and PD15: to 55 % (R1a, **) and 51 % (R2, **), respectively. Contrarily, PM level of the cognate G-proteins Gi1/Gi2alpha, Gi3alpha, Goalpha, Gzalpha and Gbeta was unchanged in the course of the whole postnatal period of brain cortex development. Maturation of GABAB-R cascade was substantially different from ontogenetic profile of Na, K-ATPase, which was low at birth and increased between the birth and PD25. In adult rats, membrane content of Na, K-ATPase was 3-times higher than around the birth (en)
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Title
| - Plasma Membrane Density of GABA(B)-R1a, GABA(B)-R1b, GABA-R2 and Trimeric G-proteins in the Course of Postnatal Development of Rat Brain Cortex
- Plasma Membrane Density of GABA(B)-R1a, GABA(B)-R1b, GABA-R2 and Trimeric G-proteins in the Course of Postnatal Development of Rat Brain Cortex (en)
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skos:prefLabel
| - Plasma Membrane Density of GABA(B)-R1a, GABA(B)-R1b, GABA-R2 and Trimeric G-proteins in the Course of Postnatal Development of Rat Brain Cortex
- Plasma Membrane Density of GABA(B)-R1a, GABA(B)-R1b, GABA-R2 and Trimeric G-proteins in the Course of Postnatal Development of Rat Brain Cortex (en)
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skos:notation
| - RIV/67985823:_____/13:00420970!RIV14-GA0-67985823
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(GAP207/12/0919), P(GBP304/12/G069)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/13:00420970
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - GABAB-receptors; postnatal development; rat brain cortex; G-proteins; Na, K-ATPase (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Svoboda, Petr
- Kagan, Dmytro
- Dlouhá, Kateřina
- Roubalová, Lenka
- Ujčíková, Hana
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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