About: Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications     Goto   Sponge   NotDistinct   Permalink

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  • Several heterocyclic N-piperidine substituted salts were synthesized that were found to inhibit the specific binding of the antagonists of muscarinic receptors. One of the compounds was found tobe 3 to 8 times more potent at M2 than other subtypes of muscarinic receptors in competition binding and selective for the M1 receptors over M3 and M5 in antagonizing accumulation of inositol phosphates induced by muscarinic agonist carbachol
  • Several heterocyclic N-piperidine substituted salts were synthesized that were found to inhibit the specific binding of the antagonists of muscarinic receptors. One of the compounds was found tobe 3 to 8 times more potent at M2 than other subtypes of muscarinic receptors in competition binding and selective for the M1 receptors over M3 and M5 in antagonizing accumulation of inositol phosphates induced by muscarinic agonist carbachol (en)
Title
  • Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications
  • Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications (en)
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  • Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications
  • Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications (en)
skos:notation
  • RIV/67985823:_____/13:00420861!RIV14-GA0-67985823
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  • I, P(GA305/09/0681)
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  • 6
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  • 109543
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  • RIV/67985823:_____/13:00420861
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  • N-piperidine substituted salts; muscarinic receptor antagonists; selectivity (en)
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  • US - Spojené státy americké
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  • [FC6B1C038714]
http://linked.open...i/riv/nazevZdroje
  • Journal of Heterocyclic Chemistry
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  • 50
http://linked.open...iv/tvurceVysledku
  • Jakubík, Jan
  • Randáková, Alena
  • Avila, C.
  • Boulos, J.
http://linked.open...ain/vavai/riv/wos
  • 000327293700018
issn
  • 0022-152X
number of pages
http://bibframe.org/vocab/doi
  • 10.1002/jhet.1742
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