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rdf:type
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Description
| - Integrins emerge nowadays as crucial actors of tumor aggressiveness and resistance to therapies. Integrin alpha 5 beta 1, the fibronectin receptor, determines malignant properties of colon carcinoma which is one of the most important causes of cancer-related deaths in the world. Results emphasize the crucial role of alpha 5 beta 1 integrin in colon tumors. Data also suggest that interfering with the integrin alpha 5 beta 1 through the reactivation of p53 by Nutlin-3a may be of valuable interest as a new therapeutic option for colon tumors expressing high level of the integrin and a wild type p53
- Integrins emerge nowadays as crucial actors of tumor aggressiveness and resistance to therapies. Integrin alpha 5 beta 1, the fibronectin receptor, determines malignant properties of colon carcinoma which is one of the most important causes of cancer-related deaths in the world. Results emphasize the crucial role of alpha 5 beta 1 integrin in colon tumors. Data also suggest that interfering with the integrin alpha 5 beta 1 through the reactivation of p53 by Nutlin-3a may be of valuable interest as a new therapeutic option for colon tumors expressing high level of the integrin and a wild type p53 (en)
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Title
| - Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target alpha 5 integrin in colon cancer cells
- Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target alpha 5 integrin in colon cancer cells (en)
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skos:prefLabel
| - Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target alpha 5 integrin in colon cancer cells
- Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target alpha 5 integrin in colon cancer cells (en)
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skos:notation
| - RIV/67985823:_____/13:00395456!RIV14-AV0-67985823
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/13:00395456
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - colon cancer; integrin alpha 5 beta 1; p53; Nutlin-3a (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Teisinger, Jan
- Martin, S.
- Dontenwill, M.
- Janoušková, Hana
- Noulet, F.
- Choulier, L.
- Lehmann, M.
- Lelong-Rebel, I.
- Ray, A. M.
- Schaffner, F.
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.canlet.2013.03.018
|