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rdf:type
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Description
| - The vanilloid transient receptor potential channel TRPV1 is a molecular integrator of noxious stimuli, including capsaicin, heat and protons. To explore the function of S1 in TRPV1, we used tryptophan-scanning mutagenesis and characterized the responses to capsaicin and protons. We propose that the S1 domain contains a functionally important region that may be specifically involved in TRPV1 channel gating, and thus be important for the energetic coupling between S1-S4 sensor activation and gate opening
- The vanilloid transient receptor potential channel TRPV1 is a molecular integrator of noxious stimuli, including capsaicin, heat and protons. To explore the function of S1 in TRPV1, we used tryptophan-scanning mutagenesis and characterized the responses to capsaicin and protons. We propose that the S1 domain contains a functionally important region that may be specifically involved in TRPV1 channel gating, and thus be important for the energetic coupling between S1-S4 sensor activation and gate opening (en)
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Title
| - Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel
- Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel (en)
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skos:prefLabel
| - Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel
- Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel (en)
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skos:notation
| - RIV/67985823:_____/13:00394052!RIV14-GA0-67985823
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(GA305/09/0081), P(GAP301/10/1159), P(GBP304/12/G069)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/13:00394052
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - vanilloid receptor subtype 1; transient receptor potential; gating; tryptophan-scanning; mutagenesis (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Biochimica Et Biophysica Acta-Molecular Cell Research
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Teisinger, Jan
- Vlachová, Viktorie
- Boukalová, Štěpána
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.bbamcr.2012.11.017
|