About: Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel

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About: Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The vanilloid transient receptor potential channel TRPV1 is a molecular integrator of noxious stimuli, including capsaicin, heat and protons. To explore the function of S1 in TRPV1, we used tryptophan-scanning mutagenesis and characterized the responses to capsaicin and protons. We propose that the S1 domain contains a functionally important region that may be specifically involved in TRPV1 channel gating, and thus be important for the energetic coupling between S1-S4 sensor activation and gate opening The vanilloid transient receptor potential channel TRPV1 is a molecular integrator of noxious stimuli, including capsaicin, heat and protons. To explore the function of S1 in TRPV1, we used tryptophan-scanning mutagenesis and characterized the responses to capsaicin and protons. We propose that the S1 domain contains a functionally important region that may be specifically involved in TRPV1 channel gating, and thus be important for the energetic coupling between S1-S4 sensor activation and gate opening (en)
Title	Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel (en)
skos:prefLabel	Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel (en)
skos:notation	RIV/67985823:_____/13:00394052!RIV14-GA0-67985823
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GA305/09/0081), P(GAP301/10/1159), P(GBP304/12/G069)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Vlachová, Viktorie Boukalová, Štěpána Teisinger, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	100576
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/13:00394052
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	vanilloid receptor subtype 1; transient receptor potential; gating; tryptophan-scanning; mutagenesis (en)
http://linked.open.../riv/klicoveSlovo	gating tryptophan-scanning vanilloid receptor subtype 1 mutagenesis transient receptor potential
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[77BA58AAC0B7]
http://linked.open...i/riv/nazevZdroje	Biochimica Et Biophysica Acta-Molecular Cell Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Project of excellence in the field of neuroscience Structural and functional determinants on TRPV channels Activation and regulation mechanisms of nociceptor-specific transient receptor potential channels: physiological role in acute and chronic pain
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	1833
http://linked.open...iv/tvurceVysledku	Teisinger, Jan Vlachová, Viktorie Boukalová, Štěpána
http://linked.open...ain/vavai/riv/wos	000315308100010
issn	0167-4889
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bbamcr.2012.11.017

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