About: Pharmacological activation of mitochondrial BKCa channels protects isolated cardiomyocytes against simulated reperfusion-induced injury

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About: Pharmacological activation of mitochondrial BKCa channels protects isolated cardiomyocytes against simulated reperfusion-induced injury Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The results indicate that pharmacological activation of mitochondrial large-conductance calcium-activated potassium channels effectively protects isolated cardiomyocytes against injury associated with simulated reperfusion. The mechanism of this form of protection requires signaling via reactive oxygen species, but not the activation of the pro-survival phosphatidylinositol-3-kinase pathway The results indicate that pharmacological activation of mitochondrial large-conductance calcium-activated potassium channels effectively protects isolated cardiomyocytes against injury associated with simulated reperfusion. The mechanism of this form of protection requires signaling via reactive oxygen species, but not the activation of the pro-survival phosphatidylinositol-3-kinase pathway (en)
Title	Pharmacological activation of mitochondrial BKCa channels protects isolated cardiomyocytes against simulated reperfusion-induced injury Pharmacological activation of mitochondrial BKCa channels protects isolated cardiomyocytes against simulated reperfusion-induced injury (en)
skos:prefLabel	Pharmacological activation of mitochondrial BKCa channels protects isolated cardiomyocytes against simulated reperfusion-induced injury Pharmacological activation of mitochondrial BKCa channels protects isolated cardiomyocytes against simulated reperfusion-induced injury (en)
skos:notation	RIV/67985823:_____/13:00392285!RIV14-GA0-67985823
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GAP303/12/1162), P(IAA500110804), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Hlaváčková, Markéta Kolář, František Borchert, Gudrun H.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	96000
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/13:00392285
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	potassium channels; cardiomyocytes; mitochondria; ischemia/reperfusion; cytoprotection; reactive oxygen species (en)
http://linked.open.../riv/klicoveSlovo	ischemia/reperfusion cytoprotection mitochondria cardiomyocytes potassium channels reactive oxygen species
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[2E2309CE1D8A]
http://linked.open...i/riv/nazevZdroje	Experimental Biology and Medicine
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Interaction between sustained forms of cardioprotection induced by adaptation to chronic hypoxia and regular exercise training. Anoxic tolerance and Ca2+ homeostasis of right and left ventricular myocytes isolated from chronically hypoxic hearts
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	238
http://linked.open...iv/tvurceVysledku	Kolář, František Borchert, Gudrun H. Hlaváčková, Markéta
http://linked.open...ain/vavai/riv/wos	000317808900013
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	1535-3702
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1177/1535370212474596

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