About: RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation     Goto   Sponge   NotDistinct   Permalink

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  • RNA editing by adenosine deaminases that act on RNA (ADARs) diversifies the transcriptome by changing adenosines to inosines. Have isolated three proteins that repress ADAR2-mediated RNA editing. RPS14, SFRS9 and DDX 15 interact with RNA. Overexpression or depletion of these proteins can decrease or increase editing levels by 15 %, thus allowing a modulation of RNA editing up to 30 %. Expression of the three factors decreases during mouse brain development. Moreover, expression levels of SFRS9 and DDX15 respond strongly to neuronal stimulation or repression
  • RNA editing by adenosine deaminases that act on RNA (ADARs) diversifies the transcriptome by changing adenosines to inosines. Have isolated three proteins that repress ADAR2-mediated RNA editing. RPS14, SFRS9 and DDX 15 interact with RNA. Overexpression or depletion of these proteins can decrease or increase editing levels by 15 %, thus allowing a modulation of RNA editing up to 30 %. Expression of the three factors decreases during mouse brain development. Moreover, expression levels of SFRS9 and DDX15 respond strongly to neuronal stimulation or repression (en)
Title
  • RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation
  • RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation (en)
skos:prefLabel
  • RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation
  • RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation (en)
skos:notation
  • RIV/67985823:_____/13:00391765!RIV14-AV0-67985823
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  • RIV/67985823:_____/13:00391765
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  • RNA; adenosine; ADAR2 (en)
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  • GB - Spojené království Velké Británie a Severního Irska
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  • [53E07DC894F4]
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  • Nucleic Acids Research
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  • 41
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  • Balík, Aleš
  • Garncarz, W.
  • Handl, C.
  • Jantsch, M. F.
  • Pusch, O.
  • Tariq, A.
http://linked.open...ain/vavai/riv/wos
  • 000318062000047
issn
  • 0305-1048
number of pages
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  • 10.1093/nar/gks1353
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