About: Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2)

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About: Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2) Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In control animals activities of individual antioxidant enzymes revealed different changes during the studied postnatal period (PD12-PD47).In animals in which seizures were induced by DL-homocysteic acid, the activity of total SOD, SOD1 and particularly SOD2 significantly increased at 20 h and 6 days of survival following the seizures.Upregulation of SOD2 was also confirmed in mitochondria at the protein level by immunoblotting.The activities of other antioxidant enzymes did not differ from the appropriate controls. The findings suggest that antioxidant defense in brain of immature animals during seizures is limited and may thus contribute to the occurrence of oxidative stress In control animals activities of individual antioxidant enzymes revealed different changes during the studied postnatal period (PD12-PD47).In animals in which seizures were induced by DL-homocysteic acid, the activity of total SOD, SOD1 and particularly SOD2 significantly increased at 20 h and 6 days of survival following the seizures.Upregulation of SOD2 was also confirmed in mitochondria at the protein level by immunoblotting.The activities of other antioxidant enzymes did not differ from the appropriate controls. The findings suggest that antioxidant defense in brain of immature animals during seizures is limited and may thus contribute to the occurrence of oxidative stress (en)
Title	Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2) Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2) (en)
skos:prefLabel	Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2) Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2) (en)
skos:notation	RIV/67985823:_____/13:00391719!RIV14-MSM-67985823
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA309/08/0292), P(GAP303/10/0999), P(LL1204), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Houštěk, Josef Nůsková, Hana Ješina, Pavel Folbergrová, Jaroslava
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	61452
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/13:00391719
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	immature rats; DL-homocysteic acid-induced seizures; long periods of survival following the seizures; the antioxidant enzyme activities; protein levels of SOD; upregulation of SOD2 following the seizures (en)
http://linked.open.../riv/klicoveSlovo	immature rats DL-homocysteic acid-induced seizures long periods of survival following the seizures protein levels of SOD the antioxidant enzyme activities upregulation of SOD2 following the seizures
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[3EED15466A24]
http://linked.open...i/riv/nazevZdroje	International Journal of Developmental Neuroscience
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Role of oxidative stress in brain injury following status epilepticus induced in immature rats The role of nitric oxide in experimentally induced seizures and epileptogenesis in rats. Genetic analysis of mitochondrial proteome: Integration of mitochondrial-nuclear epistasis with disease phenotypes in the rat
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Houštěk, Josef Ješina, Pavel Nůsková, Hana Folbergrová, Jaroslava
http://linked.open...ain/vavai/riv/wos	000314557500005
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0736-5748
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ijdevneu.2012.11.011

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