About: Single amino acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors

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About: Single amino acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Using chimeric and mutated GluN1 subunits expressed in heterologous cells, we identified a single amino acid residue within the fourth membrane domain (M4) of GluN1 subunit, L830, that regulates the surface number of NMDA receptors. Our experiments show that this residue is not critical for the interaction between GluN1 and GluN2 subunits or for the formation of functional receptors, but rather that it regulates the forward trafficking of the NMDA receptors Using chimeric and mutated GluN1 subunits expressed in heterologous cells, we identified a single amino acid residue within the fourth membrane domain (M4) of GluN1 subunit, L830, that regulates the surface number of NMDA receptors. Our experiments show that this residue is not critical for the interaction between GluN1 and GluN2 subunits or for the formation of functional receptors, but rather that it regulates the forward trafficking of the NMDA receptors (en)
Title	Single amino acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors Single amino acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors (en)
skos:prefLabel	Single amino acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors Single amino acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors (en)
skos:notation	RIV/67985823:_____/12:00386496!RIV13-GA0-67985823
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GAP303/11/0075), P(GAP303/12/1464), P(GBP304/12/G069), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Vyklický ml., Ladislav Kaniaková, Martina Lichnerová, Katarina Horák, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	168125
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/12:00386496
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	assembly; glutamate receptor; ion channel (en)
http://linked.open.../riv/klicoveSlovo	assembly glutamate receptor ion channel
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2D23164D5F44]
http://linked.open...i/riv/nazevZdroje	Journal of Neurochemistry
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Neurosteroid modulation of NMDA receptors Project of excellence in the field of neuroscience Role of membrane domains of NR1 and NR2 subunits in the assembly and trafficking of the NMDA receptor to the cell surface
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	123
http://linked.open...iv/tvurceVysledku	Horák, Martin Vyklický ml., Ladislav Kaniaková, Martina Lichnerová, Katarina
http://linked.open...ain/vavai/riv/wos	000309743600007
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0022-3042
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/jnc.12002

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