About: Key Amino Acid Residues within the Third Membrane Domains of NR1 and NR2 Subunits Contribute to the Regulation of the Surface Delivery of N-methyl-D-aspartate Receptors

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About: Key Amino Acid Residues within the Third Membrane Domains of NR1 and NR2 Subunits Contribute to the Regulation of the Surface Delivery of N-methyl-D-aspartate Receptors Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Using truncated and mutated NMDA receptor subunits expressed in heterologous cells, we found that the M3 domains of both NR1 and NR2 subunits contain at least two structural determinants that regulate the number of surface functional NMDA receptors. These structural determinants are neither critical for the interaction between the NR1 and NR2 subunits nor for the formation of the functional receptors, but rather they regulate the release of the receptors from the ER Using truncated and mutated NMDA receptor subunits expressed in heterologous cells, we found that the M3 domains of both NR1 and NR2 subunits contain at least two structural determinants that regulate the number of surface functional NMDA receptors. These structural determinants are neither critical for the interaction between the NR1 and NR2 subunits nor for the formation of the functional receptors, but rather they regulate the release of the receptors from the ER (en)
Title	Key Amino Acid Residues within the Third Membrane Domains of NR1 and NR2 Subunits Contribute to the Regulation of the Surface Delivery of N-methyl-D-aspartate Receptors Key Amino Acid Residues within the Third Membrane Domains of NR1 and NR2 Subunits Contribute to the Regulation of the Surface Delivery of N-methyl-D-aspartate Receptors (en)
skos:prefLabel	Key Amino Acid Residues within the Third Membrane Domains of NR1 and NR2 Subunits Contribute to the Regulation of the Surface Delivery of N-methyl-D-aspartate Receptors Key Amino Acid Residues within the Third Membrane Domains of NR1 and NR2 Subunits Contribute to the Regulation of the Surface Delivery of N-methyl-D-aspartate Receptors (en)
skos:notation	RIV/67985823:_____/12:00386492!RIV13-GA0-67985823
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GAP303/11/0075), P(GAP303/12/1464), P(GBP304/12/G069), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	31
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Vyklický ml., Ladislav Vyklický, Vojtěch Kaniaková, Martina Kořínek, Miloslav Lichnerová, Katarina Krausová, Barbora Horák, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	144597
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/12:00386492
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NMDA receptor; NR1; NR2 (en)
http://linked.open.../riv/klicoveSlovo	NMDA receptor NR1 NR2
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DCC3F8B931EF]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Neurosteroid modulation of NMDA receptors Project of excellence in the field of neuroscience Role of membrane domains of NR1 and NR2 subunits in the assembly and trafficking of the NMDA receptor to the cell surface
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	287
http://linked.open...iv/tvurceVysledku	Horák, Martin Vyklický ml., Ladislav Vyklický, Vojtěch Kaniaková, Martina Kořínek, Miloslav Krausová, Barbora Lichnerová, Katarina
http://linked.open...ain/vavai/riv/wos	000306916300067
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0021-9258
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1074/jbc.M112.339085

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