About: YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation

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About: YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We studied the functional involvement of human YME1L in mitochondrial biogenesis and homeostasis using stable RNAi and expression experiments in HEK293 cells. We found that YME1L performs proteolytic control of mitochondrial OXPHOS biogenesis, functions antiapoptotic and is required for normal cell proliferation. Our results stress the importance of mitochondrial protein quality control for mitochondrial and cellular integrity and demonstrate novel mechanisms controlling respiratory chain biogenesis We studied the functional involvement of human YME1L in mitochondrial biogenesis and homeostasis using stable RNAi and expression experiments in HEK293 cells. We found that YME1L performs proteolytic control of mitochondrial OXPHOS biogenesis, functions antiapoptotic and is required for normal cell proliferation. Our results stress the importance of mitochondrial protein quality control for mitochondrial and cellular integrity and demonstrate novel mechanisms controlling respiratory chain biogenesis (en)
Title	YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation (en)
skos:prefLabel	YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation (en)
skos:notation	RIV/67985823:_____/12:00385215!RIV13-AV0-67985823
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(1M0520), P(GPP305/10/P414), S, Z(AV0Z50110509), Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Houštěk, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	181245
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/12:00385215
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mitochondria; respiratory chain; AAA proteases; YME1L; apoptosis; HEK293 cells (en)
http://linked.open.../riv/klicoveSlovo	mitochondria apoptosis AAA proteases HEK293 cells YME1L respiratory chain
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D90E020E3043]
http://linked.open...i/riv/nazevZdroje	Molecular Biology of the Cell
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Applied Genomics Structure-function characterization of human i-AAA protease, Yme1l1, and translocase Oxa1l in the biogenesis of the oxidative phosphorylation system
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Houštěk, Josef Zeman, J. Wenchich, L. Fornůsková, D. Kostková, O. Stibůrek, L. Vinšová, K. Česneková, J.
http://linked.open...ain/vavai/riv/wos	000301453700019
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	1059-1524
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1091/mbc.E11-08-0674

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