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  • Perfluorobenzoates and perfluorobenzamides in position 17 of 5beta-androstan-3alpha-ol were synthesized from the corresponding 17-hydroxy and 17-amino derivatives. Their glutamates or sulfates were tested for inhibitory activity at NMDA receptors. 17alpha-epimers were more potent than their 17b-substituted analogs. The series was expanded with perfluorobenzoate of 11alpha-hydroxy pregnanolone. From nine tested compounds, four of them exhibit very good inhibition activity and can serve as promising leads for photolabeling experiments.
  • Perfluorobenzoates and perfluorobenzamides in position 17 of 5beta-androstan-3alpha-ol were synthesized from the corresponding 17-hydroxy and 17-amino derivatives. Their glutamates or sulfates were tested for inhibitory activity at NMDA receptors. 17alpha-epimers were more potent than their 17b-substituted analogs. The series was expanded with perfluorobenzoate of 11alpha-hydroxy pregnanolone. From nine tested compounds, four of them exhibit very good inhibition activity and can serve as promising leads for photolabeling experiments. (en)
Title
  • Neuroactive steroids with perfluorobenzoyl group
  • Neuroactive steroids with perfluorobenzoyl group (en)
skos:prefLabel
  • Neuroactive steroids with perfluorobenzoyl group
  • Neuroactive steroids with perfluorobenzoyl group (en)
skos:notation
  • RIV/67985823:_____/12:00380142!RIV13-TA0-67985823
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(GAP303/12/1464), P(GBP304/12/G069), P(TE01020028)
http://linked.open...iv/cisloPeriodika
  • 12
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  • 153868
http://linked.open...ai/riv/idVysledku
  • RIV/67985823:_____/12:00380142
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  • neuroactive steroids; synthesis; perfluorobenzoates; NMDA receptor (en)
http://linked.open.../riv/klicoveSlovo
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  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [4A01F537429A]
http://linked.open...i/riv/nazevZdroje
  • Steroids
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  • 77
http://linked.open...iv/tvurceVysledku
  • Buděšínský, Miloš
  • Pouzar, Vladimír
  • Vyklický ml., Ladislav
  • Vyklický, Vojtěch
  • Černý, Ivan
  • Krausová, Barbora
http://linked.open...ain/vavai/riv/wos
  • 000310480800008
issn
  • 0039-128X
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.steroids.2012.07.004
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