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rdf:type
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Description
| - Perfluorobenzoates and perfluorobenzamides in position 17 of 5beta-androstan-3alpha-ol were synthesized from the corresponding 17-hydroxy and 17-amino derivatives. Their glutamates or sulfates were tested for inhibitory activity at NMDA receptors. 17alpha-epimers were more potent than their 17b-substituted analogs. The series was expanded with perfluorobenzoate of 11alpha-hydroxy pregnanolone. From nine tested compounds, four of them exhibit very good inhibition activity and can serve as promising leads for photolabeling experiments.
- Perfluorobenzoates and perfluorobenzamides in position 17 of 5beta-androstan-3alpha-ol were synthesized from the corresponding 17-hydroxy and 17-amino derivatives. Their glutamates or sulfates were tested for inhibitory activity at NMDA receptors. 17alpha-epimers were more potent than their 17b-substituted analogs. The series was expanded with perfluorobenzoate of 11alpha-hydroxy pregnanolone. From nine tested compounds, four of them exhibit very good inhibition activity and can serve as promising leads for photolabeling experiments. (en)
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Title
| - Neuroactive steroids with perfluorobenzoyl group
- Neuroactive steroids with perfluorobenzoyl group (en)
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skos:prefLabel
| - Neuroactive steroids with perfluorobenzoyl group
- Neuroactive steroids with perfluorobenzoyl group (en)
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skos:notation
| - RIV/67985823:_____/12:00380142!RIV13-TA0-67985823
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(GAP303/12/1464), P(GBP304/12/G069), P(TE01020028)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/12:00380142
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - neuroactive steroids; synthesis; perfluorobenzoates; NMDA receptor (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Buděšínský, Miloš
- Pouzar, Vladimír
- Vyklický ml., Ladislav
- Vyklický, Vojtěch
- Černý, Ivan
- Krausová, Barbora
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.steroids.2012.07.004
|