About: Hypoxia-induced lipid peroxidation in the brain during postnatal ontogenesis

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About: Hypoxia-induced lipid peroxidation in the brain during postnatal ontogenesis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The brain tissue has the high rate of oxidative metabolic activity, high concentration of polyunsaturated fatty acids in membrane lipids, presence of iron and low capacity of antioxidant enzymes, which makes the brain very susceptible to reactive oxygen species action and lipid peroxidation formation. Membranes of brain cortex show a higher production of thiobarbituric acid-reactive substances (TBARS) in prooxidant system (ADP-Fe3+/NADPH) then membranes from the heart or kidney. The experimental model of short-term hypoxia shows remarkable increase in TBARS in four different parts of the rat brain (cortex, subcortical structures, cerebellum and medulla oblongata) during the postnatal development of Wistar rats of both sexes. Young rats and males are more sensitive to oxygen changes than adult rats and female, respectively. Rats pretreated with L-carnitine (and its derivatives) have lower TBARS levels after exposure to hypobaric hypoxia The brain tissue has the high rate of oxidative metabolic activity, high concentration of polyunsaturated fatty acids in membrane lipids, presence of iron and low capacity of antioxidant enzymes, which makes the brain very susceptible to reactive oxygen species action and lipid peroxidation formation. Membranes of brain cortex show a higher production of thiobarbituric acid-reactive substances (TBARS) in prooxidant system (ADP-Fe3+/NADPH) then membranes from the heart or kidney. The experimental model of short-term hypoxia shows remarkable increase in TBARS in four different parts of the rat brain (cortex, subcortical structures, cerebellum and medulla oblongata) during the postnatal development of Wistar rats of both sexes. Young rats and males are more sensitive to oxygen changes than adult rats and female, respectively. Rats pretreated with L-carnitine (and its derivatives) have lower TBARS levels after exposure to hypobaric hypoxia (en)
Title	Hypoxia-induced lipid peroxidation in the brain during postnatal ontogenesis Hypoxia-induced lipid peroxidation in the brain during postnatal ontogenesis (en)
skos:prefLabel	Hypoxia-induced lipid peroxidation in the brain during postnatal ontogenesis Hypoxia-induced lipid peroxidation in the brain during postnatal ontogenesis (en)
skos:notation	RIV/67985823:_____/12:00380085!RIV13-GA0-67985823
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(1M0510), P(GAP304/12/0259), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	Suppl.1
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Vokurková, Martina Rauchová, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	140147
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/12:00380085
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hypobaric hypoxia; reactive oxygen species (ROS); polyunsaturated fatty acids; Na; K-ATPase; catalase; L-carnitine (en)
http://linked.open.../riv/klicoveSlovo	polyunsaturated fatty acids K-ATPase Na reactive oxygen species (ROS) catalase L-carnitine hypobaric hypoxia
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[90AD046C940E]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Mutual interactions of various vasoactive systems, reactive oxygen species and G proteins in experimental hypertension Centre for cardiovascular research
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	61
http://linked.open...iv/tvurceVysledku	Rauchová, Hana Vokurková, Martina Koudelová, J.
http://linked.open...ain/vavai/riv/wos	000307133700006
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0862-8408
number of pages	7 (xsd:int)

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