About: Conserved ectodomain cysteines are essential for rat P2X7 receptor trafficking

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About: Conserved ectodomain cysteines are essential for rat P2X7 receptor trafficking Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this study was to understand the role of conserved ectodomain cysteine residues in P2X7 receptor function. Single- and double-point threonine mutants, other than C119T-P2X7, responded to application of BzATP and ATP with small amplitude currents or were practically non-functional. The mutagenesis-induced loss of function was due to decreased cell-surface receptor expression The aim of this study was to understand the role of conserved ectodomain cysteine residues in P2X7 receptor function. Single- and double-point threonine mutants, other than C119T-P2X7, responded to application of BzATP and ATP with small amplitude currents or were practically non-functional. The mutagenesis-induced loss of function was due to decreased cell-surface receptor expression (en)
Title	Conserved ectodomain cysteines are essential for rat P2X7 receptor trafficking Conserved ectodomain cysteines are essential for rat P2X7 receptor trafficking (en)
skos:prefLabel	Conserved ectodomain cysteines are essential for rat P2X7 receptor trafficking Conserved ectodomain cysteines are essential for rat P2X7 receptor trafficking (en)
skos:notation	RIV/67985823:_____/12:00380084!RIV13-GA0-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/07/0681), P(GD305/08/H037), P(GPP304/12/P371), P(IAA500110910), P(LC554), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Zemková, Hana Jindřichová, Marie Kuzyk, Pavlo
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	128495
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/12:00380084
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	purinergic P2X receptors; ATP-gated channels; disulfide bonds; trafficking (en)
http://linked.open.../riv/klicoveSlovo	purinergic P2X receptors trafficking ATP-gated channels disulfide bonds
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[6FFDD8B257BD]
http://linked.open...i/riv/nazevZdroje	Purinergic Signalling
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Electrical excitability and calcium signaling in anterior pituitary cells Physiology of animal cell (2) Structure and function of receptors activated by extracellular ATP Neuroscience Centre Study on structure-function relations and modulations of the proapoptotic P2X7 receptor
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Zemková, Hana Jindřichová, Marie Kuzyk, Pavlo Li, S. Stojilkovic, S. S.
http://linked.open...ain/vavai/riv/wos	000304592200016
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	1573-9538
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s11302-012-9291-x

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