About: Chronic endothelin A receptor blockade attenuates contribution of sympathetic nervous system to salt hypertension development in adult but not in young Dahl rats

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The role of endothelin-1 in the development or the maintenance of salt hypertension induced in young (4-week-old) or adult (12-week-old) Dahl rats was compared. Acute ET(A) receptor blockade lowered BP in both age groups of salt hypertensive Dahl rats more than in rats fed a low-salt diet (but without any age-dependent difference). Chronic ET(A) receptor blockade strongly attenuated the development of salt hypertension and cardiac hypertrophy in adult rats, but it had no significant effects on salt hypertension in young animals. Pronounced BP reduction induced in adult salt hypertensive rats by chronic ambrisentan treatment was attributed to attenuated sympathetic BP component, without changes in nitric oxide (NO)-dependent BP regulation. Thus ET(A) receptor-mediated ET-1 effects play an important role in salt hypertension of adult but not young Dahl rats The role of endothelin-1 in the development or the maintenance of salt hypertension induced in young (4-week-old) or adult (12-week-old) Dahl rats was compared. Acute ET(A) receptor blockade lowered BP in both age groups of salt hypertensive Dahl rats more than in rats fed a low-salt diet (but without any age-dependent difference). Chronic ET(A) receptor blockade strongly attenuated the development of salt hypertension and cardiac hypertrophy in adult rats, but it had no significant effects on salt hypertension in young animals. Pronounced BP reduction induced in adult salt hypertensive rats by chronic ambrisentan treatment was attributed to attenuated sympathetic BP component, without changes in nitric oxide (NO)-dependent BP regulation. Thus ET(A) receptor-mediated ET-1 effects play an important role in salt hypertension of adult but not young Dahl rats (en)
Title	Chronic endothelin A receptor blockade attenuates contribution of sympathetic nervous system to salt hypertension development in adult but not in young Dahl rats Chronic endothelin A receptor blockade attenuates contribution of sympathetic nervous system to salt hypertension development in adult but not in young Dahl rats (en)
skos:prefLabel	Chronic endothelin A receptor blockade attenuates contribution of sympathetic nervous system to salt hypertension development in adult but not in young Dahl rats Chronic endothelin A receptor blockade attenuates contribution of sympathetic nervous system to salt hypertension development in adult but not in young Dahl rats (en)
skos:notation	RIV/67985823:_____/12:00376806!RIV13-GA0-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0510), P(GA305/09/0336), P(IAA500110902), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Vaněčková, Ivana Zicha, Josef Kuneš, Jaroslav Dobešová, Zdeňka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	127138
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/12:00376806
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Endothelin-1; salt hypertension; Dahl rats (en)
http://linked.open.../riv/klicoveSlovo	Dahl rats Endothelin-1 salt hypertension
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B3BA4C010936]
http://linked.open...i/riv/nazevZdroje	Acta Physiologica
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for cardiovascular research Mechanisms of antihypertensive action of high potassium intake in salt hypertension Neurohumoral control of calcium influx: nifedipine-sensitive component of blood pressure in experimental hypertension
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	205
http://linked.open...iv/tvurceVysledku	Kuneš, Jaroslav Vaněčková, Ivana Zicha, Josef Dobešová, Zdenka
http://linked.open...ain/vavai/riv/wos	000302154300013
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	1748-1708
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1748-1716.2011.02395.x

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