About: Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies

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About: Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The molecular mechanisms underlying the spatiotemporal development and environmental resistance of biofilms and colonies remain largely unknown. We show that a biofilm yeast colony is a finely tuned, complex ’multicellular organism, in which specialized cells jointly execute multiple protection strategies. These include a Pdr1p-regulated mechanism whereby multidrug-resistance transporters Pdr5p and Snq2p expel external compounds solely within the surface cell layers, as well as developmentally regulated production by internal cells of a selectively permeable extracellular matrix. The two mechanisms act in concert during colony development, allowing growth of new cell generations in a well protected, internal cavity of the colony. Colony architecture is strengthened by intercellular fiber connections The molecular mechanisms underlying the spatiotemporal development and environmental resistance of biofilms and colonies remain largely unknown. We show that a biofilm yeast colony is a finely tuned, complex ’multicellular organism, in which specialized cells jointly execute multiple protection strategies. These include a Pdr1p-regulated mechanism whereby multidrug-resistance transporters Pdr5p and Snq2p expel external compounds solely within the surface cell layers, as well as developmentally regulated production by internal cells of a selectively permeable extracellular matrix. The two mechanisms act in concert during colony development, allowing growth of new cell generations in a well protected, internal cavity of the colony. Colony architecture is strengthened by intercellular fiber connections (en)
Title	Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies (en)
skos:prefLabel	Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies (en)
skos:notation	RIV/67985823:_____/11:00369728!RIV12-AV0-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/08/0718), P(LC06063), P(LC531), Z(AV0Z50110509), Z(AV0Z50200510), Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kubínová, Lucie Chernyavskiy, Oleksandr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	199997
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/11:00369728
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CANDIDA-ALBICANS BIOFILMS; SACCHAROMYCES-CEREVISIAE; ABC TRANSPORTERS (en)
http://linked.open.../riv/klicoveSlovo	ABC TRANSPORTERS CANDIDA-ALBICANS BIOFILMS SACCHAROMYCES-CEREVISIAE
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A0EFE1BBAC22]
http://linked.open...i/riv/nazevZdroje	Journal of Cell Biology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Flurescence microscopy in biological and medical research Centre on molecular biology and physiology of yeast communities Role of ammonia signalling in yeast colony differentiation, development, ageing and survival: Molecular mechanisms and functions.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	194
http://linked.open...iv/tvurceVysledku	Kubínová, Lucie Palková, Z. Váchová, Libuše Chernyavskiy, Oleksandr Hlaváček, Otakar Štěpánek, L. Šťovíček, V.
http://linked.open...ain/vavai/riv/wos	000294602500006
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka Microorganisms in Research and Biotechnology Signaling and cellular response mechanisms
issn	0021-9525
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1083/jcb.201103129

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