About: Role of the Ectodomain Serine 275 in Shaping the Binding Pocket of the ATP-Gated P2X3 Receptor     Goto   Sponge   NotDistinct   Permalink

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Description
  • In this work, by exploring in silico the functional role for the left flipper located in the ectodomain region, we identified within this loop a candidate residue S275, which could contribute to the closure of the agonist-binding pocket. Testing of the S275 mutants using the patch-clamp technice revealed a crucial role for S275 in agonist binding and receptor desensitization
  • In this work, by exploring in silico the functional role for the left flipper located in the ectodomain region, we identified within this loop a candidate residue S275, which could contribute to the closure of the agonist-binding pocket. Testing of the S275 mutants using the patch-clamp technice revealed a crucial role for S275 in agonist binding and receptor desensitization (en)
Title
  • Role of the Ectodomain Serine 275 in Shaping the Binding Pocket of the ATP-Gated P2X3 Receptor
  • Role of the Ectodomain Serine 275 in Shaping the Binding Pocket of the ATP-Gated P2X3 Receptor (en)
skos:prefLabel
  • Role of the Ectodomain Serine 275 in Shaping the Binding Pocket of the ATP-Gated P2X3 Receptor
  • Role of the Ectodomain Serine 275 in Shaping the Binding Pocket of the ATP-Gated P2X3 Receptor (en)
skos:notation
  • RIV/67985823:_____/11:00365067!RIV12-AV0-67985823
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika
  • 39
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 227520
http://linked.open...ai/riv/idVysledku
  • RIV/67985823:_____/11:00365067
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • P2X3; purinergic; ATP; ATP-binding pocket; receptor (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [D4A31E48147D]
http://linked.open...i/riv/nazevZdroje
  • Biochemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 50
http://linked.open...iv/tvurceVysledku
  • Giniatullin, R.
  • Khafizov, K.
  • Skorinkin, A.
  • Petrenko, N.
  • Tvrdoňová, Vendula
http://linked.open...ain/vavai/riv/wos
  • 000295187200018
http://linked.open...n/vavai/riv/zamer
issn
  • 0006-2960
number of pages
http://bibframe.org/vocab/doi
  • 10.1021/bi200812u
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