About: Azido analogs of neuroactive steroids

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Analogs of neurosteroid pregnanolone, modified in position 17 were prepared. Compounds with 20-keto pregnane side chain replaced completely or only partially by azide were synthesized and converted into corresponding sulfates. Tests for inhibition of glutamate induced response on NMDA receptors revealed retaining of the activity in some extent, three of sulfates tested were more active than parent compound. Analogs of neurosteroid pregnanolone, modified in position 17 were prepared. Compounds with 20-keto pregnane side chain replaced completely or only partially by azide were synthesized and converted into corresponding sulfates. Tests for inhibition of glutamate induced response on NMDA receptors revealed retaining of the activity in some extent, three of sulfates tested were more active than parent compound. (en)
Title	Azido analogs of neuroactive steroids Azido analogs of neuroactive steroids (en)
skos:prefLabel	Azido analogs of neuroactive steroids Azido analogs of neuroactive steroids (en)
skos:notation	RIV/67985823:_____/11:00361126!RIV12-AV0-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/08/1498), P(GA309/07/0271), P(LC06077), P(LC554), Z(AV0Z40550506), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	10/11
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vyklický ml., Ladislav Vyklický, Vojtěch Borovská, Jiřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	187712
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/11:00361126
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	neuroactive steroids; synthesis; azides; NMDA receptor (en)
http://linked.open.../riv/klicoveSlovo	NMDA receptor neuroactive steroids azides synthesis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[41A8221DB519]
http://linked.open...i/riv/nazevZdroje	Steroids
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Synthesis and activity evaluation of NMDA receptor antagonists Study of the effects of neurosteroids and temperature on NMDA receptors Neuroscience Centre Center of Chemical Genetics
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	76
http://linked.open...iv/tvurceVysledku	Borovská, Jiřina Chodounská, Hana Pouzar, Vladimír Vidrna, Lukáš Vyklický ml., Ladislav Vyklický, Vojtěch Černý, Ivan
http://linked.open...ain/vavai/riv/wos	000294074700014
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0039-128X
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.steroids.2011.04.008

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